原发性高血压患者β_2-AR基因A46G多态性与美托洛尔降压疗效的关系  

Relationship between β2-AR gene A46G polymorphism and antihypertensive effect of metoprolol

作　　者：门琛[1] 唐康庭[1] 陈秀梅[1] 占伊扬[1] 

机构地区：[1]南京医科大学第一附属医院老年医学科,210029

出　　处：《江苏医药》2010年第18期2116-2118,共3页Jiangsu Medical Journal

基　　金：江苏省"青蓝工程"人才资助(JX10210554);江苏省六大人才高峰(IB09)

摘　　要：目的探讨原发性高血压(EH)患者β2肾上腺素能受体(β2-AR)基因A46G多态性与美托洛尔降压效果的关系。方法 EH患者54例,口服美托洛尔25mg/次,每天2次,连续服用4周;采用基因芯片技术对多态性位点分型,分析不同基因型和不同基因型组合间血压下降值的关系。结果服药4周后,β2-AR基因型患者收缩压、舒张压都较治疗前明显下降,AA+AG基因型患者舒张压下降较GG基因型患者明显(P<0.05)。结论β2-AR基因A46G多态性与美托洛尔的降压疗效相关,携带A等位基因的患者舒张压下降更为明显。Objective To investigate the relationship between β2-adrenergic receptor（β2-AR） gene A46G polymorphism and antihypertensive effect of metoprolol in Chinese Han ethnic population.Methords Fifty-four patients with essential hypertension（EH） received metoprolol 25 mg bid. for four weeks.β2-AR gene A46G polymorphism was genotyped by gene chip technigue.The relationship between the polymorphisms and the change in blood pressure was analyzed after treatment.ResultsSystolic and diastolic pressures after treatment were significantly decreased compared to those before treatment,which was more in patients with AA＋AG genotype than that in those with GG genotype（P0.05）.Conclusion β2-AR gene A46G polymorphism is assosiated with the antihypertensive effect of metoprolol.Decrease in diastolic pressure after treatment with metoprolol is more in patients carrying A allele.

关 键 词：原发性高血压 Β2肾上腺素能受体基因 单核苷酸多态性 美托洛尔 

分 类 号：R544[医药卫生—心血管疾病]