聚磷酸钙纤维增强聚右旋乳酸软骨组织工程支架材料的制备及性能  

Preparation and properties of calcium polyphosphate fiber reinforced poly (D-lactide) as cartilage tissue engineered scaffold

作　　者：王彦平[1] 张发其[1] 王秀丽[2] 朱凌云[1] 

机构地区：[1]兰州交通大学机电工程学院,甘肃省兰州市730070 [2]兰州城市学院信息工程学院,甘肃省兰州市730070

出　　处：《中国组织工程研究与临床康复》2010年第38期7045-7047,共3页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：甘肃省自然科学基金项目(096RJZA085);兰州交通大学大学生科技创新项目(DXS2010-012)资助~~

摘　　要：背景:传统的支架材料聚乳酸、聚乙醇酸及二者的共聚物,具有良好的生物相容性,并已广泛用于制造细胞传递和组织工程支架。但还存在易变形、降解时间长等缺点。目的:在前期工作的基础上,制备了聚磷酸钙纤维增强聚右旋乳酸软骨组织工程支架复合材料,对其物理、力学及降解性能进行了实验研究和理论分析,旨在验证前期优化配方的可行性。方法:以自制聚磷酸钙纤维为增强材料,聚右旋乳酸为基体材料,纤维与基体的配比为67/33,采用溶媒浇铸/粒子滤取技术与气体发泡相结合的方法制备了聚磷酸钙纤维增强聚右旋乳酸软骨组织工程支架复合材料,测试了该复合材料的物理力学性能和降解性能。结果与结论:聚磷酸钙/聚右旋乳酸支架材料具有高的孔隙率,孔隙率在80%～93%之间,压缩模量比纯聚乳酸支架的压缩模量有了明显提高,具有可控的降解性能,能为细胞的培养提供三维空间环境。结果提示聚磷酸钙纤维增强聚右旋乳酸支架复合材料的力学性能和生物降解特性基本满足软骨组织工程的要求,故可用作软骨组织工程支架材料。BACKGROUND：Conventional scaffolds,such as polylactic acid,polyglycolic acid and copolymers of the two,have good biocompatibility,and have been widely used in manufacturing cell delivery and tissue engineered scaffolds.However,they are easily deformed,and degrade for a long time.OBJECTIVE：To prepare a composite scaffold of calcium polyphosphate fiber reinforced poly （D-lactide） for cartilage tissue engineering,to perform experimental study and theoretical analysis of the physical,mechanical characteristics and degradation,and to verify the feasibility of optimizing compounding.METHODS：Taking calcium polyphosphate fiber as reinforced materials and poly （D-Lactide） as matrix materials in a ratio of 67/33,the composite scaffolds for cartilage tissue engineering were fabricated by solvent-casting particulate-leaching and gas foam methods,and their properties of physical mechanics and degradation were tested.RESULTS AND CONCLUSION：The prepared composite scaffolds exhibited high porosity,arranging 80%-93%.The scaffolds have higher compressive modulus than polylactic acid scaffolds,and showed controllable degradation characteristics,which can provide three-dimensional microenvironment for cell proliferation.The composites of calcium polyphosphate fiber reinforced poly （D-Lactide） can meet the mechanics and degradation demand of cartilage tissue engineering,so they can be used as scaffolds for cartilage tissue engineering.

关 键 词：聚磷酸钙 聚右旋乳酸 软骨 组织工程 支架 复合材料 

分 类 号：R318[医药卫生—生物医学工程]