不同支架材料构建组织工程化肌腱在运动性损伤的应用  

Different scaffolds construct tissue engineering tendon in sports injury

作　　者：侍勇[1] 谢正阳[2] 刘志元[3] 

机构地区：[1]江苏财经职业技术学院基础部,江苏省淮安市223003 [2]苏州大学体育学院,江苏省苏州市215006 [3]江西师范大学体育学院,江西省南昌市330022

出　　处：《中国组织工程研究与临床康复》2010年第38期7173-7176,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：目的:评价不同支架材料构建组织工程化肌腱的组织相容性存在问题和应用前景。方法:以"支架材料,组织工程,肌腱,组织相容性"为中文关键词;以"support material;tissue engineering muscle tendon,tissue consistence"为英文关键词,采用计算机检索1994-01/2010-03相关文章。纳入与有关生物材料与组织工程肌腱相关的文章;排除重复研究或Meta分析类文章。以32篇文献为主重点进行了讨论不同支架材料构建组织工程化肌腱的组织相容性存在问题和应用前景。结果:体外构建组织工程肌健时肌健细胞合成胶原能力最强,在现有条件下是体外构建组织工程肌腱的最佳种子细胞。而在材料方面,壳聚糖/聚乳酸羟基乙酸乳化膜是一种较理想的组织工程肌腱材料。应用组织工程技术在体外可以构建肌腱组织,施加周期性的应力可能更有利于肌腱组织的形成。结论:目前对于肌腱的组织工程研究主要集中在两方面,一是肌腱细胞的来源,二是生物支架材料的研究。目前的研究方向是以多种材料结合,并采用多种编织方法,使支架材料在具有良好生物相容性的同时,还能控制其降解速度,在支架降解的同时肌腱细胞增殖分化,并逐渐具有预想的生物力学性能,最终形成肌腱组织。OBJECTIVE：To evaluate the existing histocompatibility problems and application prospect of tissue engineering tendon constructed with different scaffold materials.METHODS：Using ＂scaffolds,tissue engineering,tendon,histocompatibility＂ in Chinese and ＂support material;tissue engineering muscle tendon,tissue consistence＂ in English as the Key words,a computer search was performed for articles between January 1994 and March 2010.Articles associated with the biomaterials and tissue engineered tendon were included;repeated study or Meta analysis articles were excluded.There are 32 articles main focusing existing histocompatibility problems and application prospect of the tissue engineering tendon constructed with different scaffold materials.RESULTS：Tissue engineered tendon constructed in vitro has the strongest collagen synthesis capacity,it is currently considered as the optimal seed cells for in vitro construction of tissue engineered tendon.As for the materials,chitosan/poly（lactic-co-glycolic acid） emulsion film is an ideal material for tissue engineered tendon.Tendon tissues can be constructed in vitro using tissue engineering technology,cyclic stress may be more conducive to the formation of tendon tissue.CONCLUSION：The present studies regarding tendon tissue engineering focus on two aspects,one is the source of tendon cells,and the other is scaffold biomaterials.The current research is a combination of a variety of materials and knitting methods,the scaffolds have good biocompatibility and the degradation rate is controllable,the scaffolds may degrade,while tendon cells proliferate and differentiate,and the desired biomechanical properties are gradually achieved,thus forming tendon tissue.

关 键 词：肌腱 组织工程 损伤修复 支架材料 聚羟基乙酸 

分 类 号：R318[医药卫生—生物医学工程]