铁过载与骨质疏松关系的研究进展  

Research progress in the relationship between iron overload and osteoporosis

作　　者：李光飞[1] 徐又佳[1] 钱忠明[2] 

机构地区：[1]苏州大学附属第二医院骨科,苏州215004 [2]香港理工大学生物化学系铁代谢实验室

出　　处：《中国骨质疏松杂志》2010年第10期794-797,共4页Chinese Journal of Osteoporosis

基　　金：江苏省医学重点人才项目(RC2007100);江苏省自然基金题(BK2008165)

摘　　要：铁作为机体必需的营养元素,起着重要的生物学功能,但是铁过多也会对细胞和组织产生危害。已经发现铁过载与骨质疏松之间存在某些联系。铁过载可能引起骨质疏松,但是此病理过程及铁的具体作用尚未明确。最近的报道认为:在实验水平上,铁过载可能抑制成骨细胞的功能并增加破骨细胞的活性;在临床水平上,骨质疏松症发生于多种与铁过载相关的疾病患者中。因此本文就体内铁过载和骨质疏松的关系的临床和实验研究作一综述。Although iron is an essential nutrient with crucial biological function in the body, too much iron is harmful to both cells and tissues. Iron overload has already been demonstrated to be associated with osteoporosis. Iron overload may cause osteoporosis. However, the pathogenesis and exact function of iron have not been clarified. The latest reports indicate that： on the experimental level, iron overload may inhibit the function of osteoblasts and increase the activity of osteoelasts. On the clinical level, osteoporosis occurs in the patients with iron overload-associated diseases. In this article the author reviews the clinical and experimental studies on the association of iron overload with osteoporosis.

关 键 词：铁 铁过载 骨质疏松 

分 类 号：R68[医药卫生—骨科学]