脂肪因子的信号转导通路及其在肥胖时的分泌改变  

Adipokine signal transduction pathways and its secretion in obese patients

作　　者：岳欣欣[1] 刘志民[1] 

机构地区：[1]第二军医大学长征医院内分泌科,上海200003

出　　处：《第二军医大学学报》2010年第10期1123-1127,共5页Academic Journal of Second Military Medical University

摘　　要：脂肪组织以往仅被看作为机体的燃料贮存库或组织器官间的填充剂,但随着一些脂肪细胞分泌的因子被发现,脂肪细胞的其他重要功能逐渐显现出来。脂肪组织还是一个内分泌器官,分泌的细胞因子通过自分泌、旁分泌和血液循环的方式作用于靶器官,在肥胖、胰岛素抵抗和2型糖尿病发病机制中发挥重要作用。本文主要就其中的脂联素、瘦素及抵抗素的信号转导通路及其在肥胖时的分泌改变作一综述。Adipose tissue is traditionally regarded only as an energy storage and a filler between tissues/organs. However, other important functions of adipose tissue begin to be discovered with the discovery of adipokines. Adipose tissue is also an endocrine organ, which secrets different kinds of adipokines, affecting the target organs through autocrine, paracrine and the blood circulation, and playing important roles in the pathogenesis of the obesity, insulin resistance and type 2 diabetes mellitus. This paper reviews the signal transduction pathways of adiponectin, leptin and resistin, and their changes during obesity.

关 键 词：脂肪因子类 信号转导通路 肥胖症 

分 类 号：R589.25[医药卫生—内分泌]