氟苯尼考混悬乳注射液对人工感染胸膜肺炎仔猪的药效学研究  

Pharmacodynamics study of florfenicol suspension emulsion against artificial contagious pleuropneumonia on pigs

作　　者：彭麟[1,2] 贺培益[1,2] 季辉 陈芳 江善祥[1] 

机构地区：[1]南京农业大学动物医学院,江苏南京210095 [2]南京威泰珐玛兽药研究有限责任公司,江苏南京211132 [3]南京思远生物工程有限公司,江苏南京211132

出　　处：《中国兽医科学》2010年第10期1067-1071,共5页Chinese Veterinary Science

基　　金：国家"十一五"科技支撑计划项目(2006BAD31B06-05)

摘　　要：为观察氟苯尼考混悬乳注射液对人工感染胸膜肺炎仔猪的疗效,选用体重8～10kg的杜×长×大三元杂交猪60头,分成6组,每组10头。除健康对照组之外,其他各组猪均滴鼻接种传染性胸膜肺炎放线杆菌菌液(1×109CFU/mL)5mL。人工接种后,用氟苯尼考混悬乳注射液肌肉注射治疗,观察并记录接种后各组猪临床表现,连续观察15d。对死亡猪剖检并取肺、肝涂TSA平板培养,检查是否有猪传染性胸膜肺炎放线杆菌,同时用标准血清进行血清学鉴定。试验结束后对存活猪称重,计算增重率。结果表明,肌肉注射20mg/kg剂量氟苯尼考混悬乳注射液,3d1次,连用2次,对治疗猪传染性胸膜肺炎具有显著的疗效。In order to investigate the efficacy of florfenicol suspension emulsion injection against artificial contagious pleuropneumonia on pigs,60 Duroc×Landrance× Yorkshire crossbred pigs of 8to 10kg body weight were divided into 6 groups according to weight and gender,and each group was with 10 pigs. Except for the control group,the pigs in the other groups were inoculated intranasally with 5mL Actinobacillus pleuropneumoniae bacteria suspension（1×109 CFU/mL）.After inoculation,the florfenicol suspen- sion emulsion injection was intramuscularly injected to the inoculated pigs.Their clinical manifestations were observed and wrote down on day 15 post-inoculation.A autopsy was made on dead pigs and their lung and liver were collected to conduct microorganisms examination using TSA plate and the standard serum. On day 15 post-experimental infection,the survival pigs of each group were weighed to obtain weight gain rate during the trial.The results indicated that intramuscular injection of 20mg/kg dose of the florfenicol suspension emulsion injection,one time every three days for two times,could gain significantly effective treatment against porcine pleuropneumonia.

关 键 词：氟苯尼考 混悬乳注射液 仔猪 胸膜肺炎 药效 

分 类 号：S859.53[农业科学—临床兽医学] S852.619[农业科学—兽医学]