珍珠滴丸的提取工艺研究  

A Study on Technology for Extraction of Pearl Drop pills

作　　者：乔希[1] 王爱民[1] 何迅[1] 李勇军[1] 郑林[1] 王永林[1] 

机构地区：[1]贵阳医学院药学院,贵州贵阳550004

出　　处：《贵阳医学院学报》2010年第5期448-450,455,共4页Journal of Guiyang Medical College

基　　金：贵州省科技计划项目[黔科合计工字(2009)4001号];贵阳市科学技术计划项目[(2009)筑科中合同字第9-3-04号]

摘　　要：目的:优化珍珠滴丸最佳提取工艺。方法:采用正交试验法,以3,4-O-二咖啡酰基-奎宁酸和甘草酸含量作为考察指标,对加水量、煎煮时间、煎煮次数、醇沉浓度等因素进行研究,对提取工艺进行优化。结果:最佳水提工艺以10倍药材量的水煎煮3次,1 h/次,最佳醇沉工艺为浓缩药液至相对密度为1.08,醇沉浓度为60%,放置12 h。结论:该提取工艺合理可行,为工业化生产提供了科学依据。Objective： To optimize extraction technology of Pearl Drop pill.Methods： Orthogonal experiments were carried out,using 3,4-O-dicaffeoyl-quinic acid and glycyrrhizic acid as evaluation indexes to develop a suitable extraction technology through studying imbitition amount,decoction duration,decoction times,and concentration of alcohol precipitation.Results： The optimal water extration condition was as follows： decocting the drug for three times in tenfold volume of water,1 hour for each time.The optimal alcohol precipitation extraction condition was as follows： the relative density of drug liquid be adjusted to 1.08,the concentration of alcohol precipitation kept 60%,and stored for 12 hours.Conclusions： This extraction technique is reasonable,feasible,and provids a scientific basis for industrial production.

关 键 词：工艺学 制药 中药化学成份 甘草酸 

分 类 号：R284.2[医药卫生—中药学]