糖通饮对糖尿病大鼠肾脏早期病变的保护作用  

Protective Effect of Traditional Chinese Medicine Tangtongyin on Rats with Diabetic Nephropathy of Early Stage

作　　者：王和强[1] 凌湘力[2] 

机构地区：[1]东莞市太平人民医院,广东东莞523900 [2]贵阳医学院附院,贵州贵阳550004

出　　处：《贵阳医学院学报》2010年第5期456-458,共3页Journal of Guiyang Medical College

基　　金：贵州省中医药管理局资助项目(200659)

摘　　要：目的:观察中药糖通饮对糖尿病大鼠肾脏早期病变的影响,为临床治疗提供实验依据。方法:35只SD雄性大鼠,随机分为正常对照组、糖通饮治疗组和模型对照组,用腹腔注射四氧嘧啶的方法复制糖尿病大鼠动物模型;8周后,检测各组大鼠血清血管内皮生长因子、尿微量白蛋白/肌酐、空腹血糖、空腹血清胰岛素、血清尿素氮、肌酐、内生肌酐清除率、肾重、肾重指数等指标。结果:中药组较模型组血管内皮生长因子、尿微量白蛋白/肌酐、空腹血糖、血清尿素氮、肌酐、肾重、肾重指数显著下降,空腹血清胰岛素、内生肌酐清除率显著升高(P<0.05或P<0.001)。结论:中药糖通饮对糖尿病大鼠早期肾脏病变有保护作用。Objective： To observe the effect of traditional chinese medicine Tangtongyin（TTY） on rats with diabetic nephropathy（DN） of early stage,and to provide an experimental basis for clinical application.Methods： Thirty-five male Wistar rats were randomly divided into three groups： normal control group（group C）,TTY treatment group（group T） and model group（group M）.The diabetic models were established by intraperitoneal injection of alloxan.Vascular endothelial growth factor（VEGF）,urine albumin（Alb）/creatinine（cr）,fasting blood glucose（FBG）,blood urea nitrogen（Bun）,serum creatinine（Scr）,creatinine clearance（Ccr）,kidney weight,and kidney weight index were detected in 8 weeks.Results： VEGF,urine Alb/cr,FBG,Bun,Scr,kidey weight and kidney weight index were lower and fasting blood insulin and Ccr were higher significantly in group T than those in group M（P〈0.05 or P〈0.001）.Conclusions： Traditional chinese medicine TTY has protective effects to DN rats in early stage.

关 键 词：糖尿病肾病 中药疗法 大鼠 

分 类 号：R692.9[医药卫生—泌尿科学] R587.1[医药卫生—外科学]