透明质酸酶、地塞米松对长春瑞滨外渗性大鼠皮肤损伤的疗效  

Comparison of the efficacies of hyaluronidase and dexamethasone on skin damage caused by vinorelbine extravasation in rats

作　　者：朱其聪[1] 罗荣城[2] 张正义[1] 王亚辉[1] 

机构地区：[1]解放军第一八七医院内三科,海口571100 [2]南方医科大学南方医院肿瘤科

出　　处：《肿瘤研究与临床》2010年第10期678-680,共3页Cancer Research and Clinic

摘　　要：目的 探讨透明质酸酶、地塞米松局部注射对长春瑞滨外渗性大鼠皮肤损伤的防治效果.方法在40只SD大鼠双后肢制作长春瑞滨血管外渗模型.随机分为5组,分别给予透明质酸酶局部注射、地塞米松局部注射、透明质酸酶联合地塞米松局部注射、0.9%氯化钠溶液局部注射,模型对照组不进行任何防治措施.观察各组大鼠1、4、8、12、18、24、30 d的损伤面积和损伤愈合时间.结果透明质酸酶组、地塞米松组、透明质酸酶联合地塞米松组、氯化钠溶液组1、4、8、12、18、24 d损伤面积均显著低于模型对照组（P＜0.05）,其中透明质酸酶组和透明质酸酶联合地塞米松组分别显著低于地塞米松组和氯化钠组（P＜0.05）;透明质酸酶组、地塞米松组、透明质酸酶联合地塞米松组、氯化钠溶液组的损伤愈合时间[（28.8±3.5）d、（28.0±2.9）d、（28.6±4.1）d、（29.8±2.6）d],显著低于模型对照组的（30.6±3.0）d,（P＜0.05）,其中透明质酸酶组和透明质酸酶联合地塞米松组的损伤愈合时间分别显著低于地塞米松组和氯化钠溶液组（P＜0.05）.结论单用透明质酸酶、地塞米松或0.9%氯化钠溶液局部注射对长春瑞滨外渗性损伤均有一定的疗效,而透明质酸酶的疗效较好;联合用药可能更有效.Objective To compare the efficacies of intralesional hyaluronidase（HAase）, intralesional dexamethasone（DEX）, and intralesional HAase plus intralesional DEX on skin damage caused by vinorelbine extravasation in a rat model. Methods After establishing an animal model with vinorelbine extravasation in each lower extremity of 40 Sprague-Dawley rats, we treated the rats with intralesional HAase,intralesional DEX, intralesional HAase plus intralesional DEX,intralesional saline,or received no treatment as control.The wound area on 1 d, 4 d, 8 d, 12 d, 18 d, 24 d, 30 d and the time of healing were observed and compared.Results The wound area on 1 d, 4 d, 8 d, 12 d, 18 d and 24 d was significantly lower in intralesional HAase group, intralesional DEX group,intralesional HAase plus intralesional DEX group,and intralesional saline group than that in control group （P 〈0.05）, and that was significantly lower in intralesional HAase group and intralesional HAase plus intralesional DEX group than that in intralesional DEX group and intralesional saline group （P 〈0.05）. The healing time was significantly shorter in 4 therapy groups than that in control group [（25.1±3.1） d, （27.9±2.8） d, （23.0±3.2） d, and （28.4±3.9） d vs.（31.2±3.0） d, P 〈0.05], and that was significantly lower in intralesional HAase group and intralesional HAase plus intralesional DEX group than that in intralesional DEX group and intralesional saline group （P 〈0.05）. Conclusion The monotherapy with intralesional HAase or intralesional DEX, with decreasing the extent of skin damage and shortening the healing time, is effective therapy for skin damage caused by vinorelbine extravasation, and the monotherapy with intralesional Haase is more efficacious. The efficacy of intralesional HAase plus intralesional DEX seems better than that of monotherapy.

关 键 词：肿瘤 实验性 透明质酸 地塞米松 长春瑞滨 诊断和治疗物质外渗 

分 类 号：R6[医药卫生—外科学]