4种抗精神病药物与精神分裂症患者糖代谢及糖化血红蛋白的关联性研究  

A comparative study between glucose metabolism, glycosylated hemoglobin and four atytypical antipsychotics in schizophrenic patients

作　　者：杨诚 陶世武 陈强 潘润德 潘天伟 李梁 李必浩 

机构地区：[1]广西壮族自治区龙泉山医院精神科,广西柳州545005

出　　处：《中国现代医学杂志》2010年第18期2816-2820,共5页China Journal of Modern Medicine

基　　金：广西壮族自治区卫生厅科研基金课题(No:Z2007026)

摘　　要：目的探讨4种非典型抗精神病药物对精神分裂症患者糖代谢的影响及与糖化血红蛋白的关系。方法 将360例精神分裂症患者随机分成4组,接受利培酮、喹硫平、阿立哌唑和齐拉西酮治疗,测定单药治疗前和治疗后8周空腹血糖、血清胰岛素及餐后2 h血糖、血清胰岛素和糖化血红蛋白。结果 利培酮、喹硫平、阿立哌唑及齐拉西酮对糖代谢及糖化血红蛋白的水平均有影响。结论 不同抗精神病药物对糖代谢及糖化血红蛋白的影响存在差异,齐拉西酮对糖代谢的影响与糖化血红蛋白无关联性。【Objective】 To study the influence of four atypical antipsychotics on glucose metabolism and glycated hemoglobin in the treatment of schizophrenic patients.【Methods】Three hundred and sixty schizophrenic inpatients were randomly divided into 4 groups,then each group received risperidone,quetiapine,aripiprazole,ziprasidone group respectively.Befor and after treaments for 8 week,the fasting and postprandial in 2 hours blood glucose,serum insulin and glycosylated hemoglobin were measured.【Results】All of risperidone,quetiapine,aripiprazole and ziprasidone had effected on the glucose metabolism and glycosylated hemoglobin.【Conclusion】Atypical antip sy-chotics effected on glucose metabolism and glycated hemoglobin in schizophrenics.Ziprasidone has not association with glucose metabolism and glycosylated hemoglobin.

关 键 词：非典型抗精神病药物 糖化血红蛋白 糖代谢 精神分裂症 

分 类 号：R974.9[医药卫生—药品]