鄂尔多斯高原碱湖钝顶螺旋藻多糖的免疫及抗肿瘤作用的研究  

Anti-tumor and immunomodulation effect of polysaccharide from Spirulina (Arthrospira) platensis in alkaline lake of Erdos plateau

作　　者：杜玲[1,2] 穆文静[2] 张兴夫[1] 赵飞艳[1] 乔辰[3] 敖长金[1] 

机构地区：[1]内蒙古农业大学动物科学与医学学院,内蒙古呼和浩特010018 [2]内蒙古师范大学生命科学与技术学院,内蒙古呼和浩特010022 [3]内蒙古农业大学生态学院,内蒙古呼和浩特010019

出　　处：《黑龙江畜牧兽医》2010年第10期5-7,共3页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金项目(30460104)

摘　　要：为了研究鄂尔多斯高原碱湖钝顶螺旋藻多糖的抗肿瘤作用和免疫作用,试验采用S180腹水瘤模型,观察鄂尔多斯高原碱湖钝顶螺旋藻多糖不同剂量组小鼠的生存时间、生存状况、肿瘤分布及瘤体外观,测定多糖对小鼠免疫器官指数的影响。结果表明:高、中、低3个剂量的钝顶螺旋藻多糖均能改善腹水瘤小鼠的生存状况,延长小鼠的生存时间,缩小肿瘤在体内的扩散范围;不同剂量组小鼠胸腺指数和脾脏指数均高于荷瘤对照组,以中剂量组作用效果最为显著(P<0.05),3个剂量组之间差异均不显著。说明鄂尔多斯高原碱湖钝顶螺旋藻多糖能够抑制肿瘤在小鼠体内的生长与扩散,改善肿瘤小鼠的生存质量,同时促进小鼠免疫器官的生长发育,从而增强免疫功能。To study the inhibition of polysaccharide from Spirulina（Arthrospira） platensis in alkaline lake of Erdos plateau to tumor and the regulative effect on immunity.The sarcoma 180（S180） was transplanted in the abdominal cavity and then the survival times,the survival states,tumor appearance,tumor distribution were observed through S180 ascites sarcoma in mice treated with the different dosages polysaccharide from S.（A.） platensis,immune organ indexes were detected.The results showed that the survival times were extended,the survival qualities were increased,the tumors were inhibited in certainly range.Immune organ indexes of S180 ascites sarcoma in mice treated with the different dosages polysaccharide were higher than S180 ascites sarcoma in mice untreated,but the effects of the medium dosage were the best significant（P0.05）.The differences were not significant compared with the different dosages.It concluded that polysaccharide from S.（A.） platensis in alkaline lake of Erdos plateau could inhibit growth and spread of S180 ascites sarcoma in mice,improve survival quality,and stimulate growth of immune organ,and enhance its,immune function.

关 键 词：鄂尔多斯高原碱湖 钝顶螺旋藻 多糖 生命延长率 免疫器官指数 

分 类 号：S852.4[农业科学—基础兽医学]