去氧鬼臼毒素-磺丁基醚-β-环糊精包合物的制备及抗肿瘤作用  

Preparation of solid inclusion complex of deoxypodophyllotoxin-SBE-β-CD and its antitumor activity

作　　者：朱雄[1] 吴葆金[1] 罗厚蔚[2] 陶磊[3] 赵卿[3] 郭青龙[3] 吴畅烜 

机构地区：[1]中国药科大学医药化工研究所 [2]中国药科大学天然药物化学教研室 [3]江苏省肿瘤发生与干预重点实验室,南京210009 [4]南京生命能科技开发有限公司,南京210016

出　　处：《中国药科大学学报》2010年第5期447-450,共4页Journal of China Pharmaceutical University

摘　　要：用正交试验优选磺丁基醚-β-环糊精对去氧鬼臼毒素的包合效果,差示扫描量热法和X射线衍射法确证包合物的形成。经包合,使去氧鬼臼毒素在水中的溶解度从约0.5 mg/L提高至约5 g/L。该包合物体外、体内活性试验证实,去氧鬼臼毒素对多种肿瘤细胞具有显著的抗肿瘤活性。The orthogonal design was used to optimize the inclusion of deoxypodophyllotoxin with sulphobutyl ether-β-cyclodextrin,and the prepared solid inclusion complex was confirmed by differential scanning calorimetry and X-ray diffration.After being included,the solubility of deoxypodophyllotoxin in water increased from 0.5 mg/L to 5 g/L.This solid inclusion complex was tested for in vitro and in vivo reveal antitumor activities,and the reslts revealed that this complex exhibited significant antitumor activity against various cancer cell lines.

关 键 词：去氧鬼臼毒素 磺丁基醚-Β-环糊精 包合物 抗肿瘤活性 

分 类 号：TQ461[化学工程—制药化工]