线粒体蛋白质的转运  

Translocation of Mitochondrial Proteins

作　　者：马军[1] 孙飞[1] 

机构地区：[1]中国科学院生物物理研究所,生物大分子国家重点实验室,北京100101

出　　处：《生物物理学报》2010年第10期880-893,共14页Acta Biophysica Sinica

基　　金：国家重点基础研究发展规划资助项目("973"计划)(2006CB806506;2006CB911001);国家自然科学基金(30721003;30970569)

摘　　要：线粒体含有约1000种蛋白质,其中99%由细胞核DNA编码,在细胞质核糖体上合成后被分别转运至线粒体的内膜或外膜上、基质或膜间隙中。由众多分子机器组成的线粒体蛋白质转运系统参与了该生物学过程的执行。线粒体DNA编码的13种蛋白质也由该系统转运至线粒体内膜。本文就线粒体蛋白质转运系统中线粒体前体蛋白质的定位分选信号、转运复合物和转运途径作简要介绍。There are about 1000 proteins located in mitochondria, of which 99% are encoded by nucleic DNA, synthesized by cytosolic ribosomes and then imported into one of the four mitochondrial compartments：matrix, inner membrane, intermembrane space and outer membrane.Several intricate molecular machines are dedicated to catalyze these processes as the mitochondrial protein translocation system.Thirteen proteins encoded by mitochondrial DNA are also translocated into inner membrane by this system.The various targeting signals of mitochondrial precursors, translocase complexes and mitochondrial protein translocation pathways will be described in the review.

关 键 词：蛋白质转运 前导序列 TOM复合物 TIM23复合物 TIM22复合物 

分 类 号：Q244[生物学—细胞生物学]