局麻药的神经阻滞作用与pH值的关系研究  

Study of Relationship between the Nerve Block Effect of Local Anesthetics and the pH

作　　者：王茹[1] 彭余楠[1] 张锋[1] 赵娟[1] 杜长江[1] 李丹[1] 张洋[2] 戴体俊[3] 

机构地区：[1]徐州医学院,麻醉学2006级2班221002 [2]徐州医学院麻醉生理学教研室 [3]徐州医学院麻醉药理学教研室

出　　处：《医学研究杂志》2010年第10期28-30,共3页Journal of Medical Research

基　　金：国家自然科学基金资助项目(30872432;30471657;39970715);江苏省自然科学基金资助项目(BK200143)

摘　　要：目的比较不同pH值的普鲁卡因和布比卡因溶液对蟾蜍坐骨神经动作电位的幅度、传导速度和腓肠肌收缩力的影响。方法制备120条蟾蜍坐骨神经腓肠肌标本,分别用pH值为3、4、5、6、7、8的普鲁卡因和布比卡因溶液浸润,测定浸润前后动作电位的幅度,传导速度和腓肠肌收缩力。结果 pH值为6的普鲁卡因和pH值为7的布比卡因溶液对蟾蜍坐骨神经动作电位的幅度,传导速度和腓肠肌收缩力影响最大。结论不同pH值的局麻药对蟾蜍坐骨神经的阻滞作用不同。Objective To compare the influence of procaine and bupivacaine under different pH on amplitude and propagation velocity of action potential of toad sciatie nerve and gastrocnemius contraction. Methods Sciatic - gastrocnemius was treated with procaine and bupivacaine hydrochlorida with pH of 3, 4, 5, 6, 7, 8, respectively. The amplitude and propagation velocity of action potential and gastroenemius contraction were recorded before and after being treated by procaine and bupivacaine. Results The amplitude and the propagation velocity of action potential of toad sciatic nerve and gastrocnemius contraction changed significantly when procaine in pH of 6 and bupivacaine in pH of 7. Conclusion The nerve block roles of local anesthetics were different under different pH conditions.

关 键 词：PH值 局麻药 动作电位 腓肠肌收缩力 

分 类 号：R339.16[医药卫生—人体生理学]