子宫内膜炎急性相蛋白与IL-6变化的研究  

Research on Change of Acute Phase Protein and IL-6 in Cows with Endometritis

作　　者：李德军[1,2] 刘运枫[1] 裴小英[2] 郭定宗[2] 

机构地区：[1]东北农业大学动物医学学院.哈尔滨150030 [2]华中农业大学动物医学院.武汉430070

出　　处：《畜牧兽医学报》2010年第10期1333-1336,共4页ACTA VETERINARIA ET ZOOTECHNICA SINICA

基　　金：国家支撑计划子课题(2006BAD04A05)

摘　　要：探讨急性相蛋白(C-反应蛋白、结合珠蛋白、血清淀粉样蛋白A)和细胞因子(IL-6)在不同程度的子宫内膜炎中的变化及其对子宫内膜炎的诊断意义。选用产后健康荷斯坦奶牛10头(N)为对照组;亚临床型子宫内膜炎组(SE),共28头;临床型子宫内膜炎组(CE),共30头,经颈静脉、子宫腔内分别获取血液样本及子宫分泌物,对其进行急性相蛋白和细胞因子的检测。结果表明,CE组和SE组血清和子宫分泌物中C-反应蛋白(CRP)、结合珠蛋白(Hp)、血清淀粉样蛋白A(SAA)和IL-6水平明显高于对照组(P<0.01),且CE组比SE组变化明显;在对照组子宫分泌物中未检测到Hp和SAA。随着子宫内细菌污染程度的加重,CRP、Hp、SAA、IL-6的水平也随着升高,血清和子宫分泌物中CRP、Hp、SAA、IL-6水平均可作为诊断子宫内膜炎的敏感指标。To observe the changes of acute phase protein and IL-6 in the serum and uterine secretions in cattle with endometritis and search their significance on diagnose.Sixty-eight cows were selected and divided into three groups：N（Normal cows）,SE（Subclinical Endometritis）and CE（Clinical endometritis）.The concentration of acute phase proteins and cytokine in serum and uterine secretions of endometritis cows were detected.The results showed that the concentrations of CRP,Hp,SAA and IL-6 in the serum and uterine secretions of cows with clinical endometritis and subclinical endometritis were higher than that of control group（P0.01）,and group CE was significant variable than group SE,but Hp and SAA were not detected in control group.The concentration of CRP,Hp,SAA and IL-6 were increased by different degree bacterial contamination in uterine and they can be the sensitive index for diagnosis with endometritis inflammation.

关 键 词：子宫内膜炎 C-反应蛋白 结合珠蛋白 血清淀粉样蛋白A 白介素-6 

分 类 号：S857.23[农业科学—临床兽医学]