新生儿肺炎克雷伯菌脓毒血症细菌的耐药性分析  

The antibiotic resistance of Klebsiella pneumoniae in neonatal sepsis

作　　者：尢灿[1] 张林[1] 聂波丽[1] 胡彬[1] 黄彩芝[1] 

机构地区：[1]湖南省儿童医院检验科,长沙410007

出　　处：《中国医师杂志》2010年第10期1337-1340,共4页Journal of Chinese Physician

摘　　要：目的 探讨新生儿肺炎克雷伯菌脓毒血症的耐药特性,为药物治疗提供新依据.方法 对本院近五年确诊新生儿肺炎克雷伯菌脓毒血症临床病例及药敏结果进行回顾性分析.结果 50例肺炎克雷伯菌脓毒血症多为医院内感染,其中检出产ESBLs菌株13株（占26%）,非产ESBLs菌株37株（占74%）,均为多重耐药菌株,药敏试验证明：对常用广谱β-内酰胺类抗生素均有超强耐药;但对亚胺培南及阿米卡星等药敏感,敏感率高达100%.结论 亚胺培南和阿米卡星均可作为新生儿肺炎克雷伯菌感染首选治疗药物.Objective To study the drug resistance of neonatal sepsis caused by Klebsiella pneumoniae and provide evidence for drug treatment. Method Retrospectively analysis was conducted on the clinical data and antibiotic resistance of Klebsiella pneumoniae in 50 neonates with sepsis. Results The majority of the 50 cases were infected in hospital. There were 13 ESBLs strains in 50 Klebsiella pneumoniae strains （26%）, and the others were negative ESBLs starins （74%）. All the strains were multidrug-resistance to the β-lactam antibiotics and only sensitive to few antibiotics such as Imipenem and Amikacin. The sensitive rate was 100%. Conclusions The first selected antibiotic for the treatment of neonatal sepsis caused by Klebsiella pnemoniae was Imipenem or Amikacin.

关 键 词：克雷伯菌 肺炎/药物作用 脓毒症/微生物学 抗药性 细菌 

分 类 号：R446.5[医药卫生—诊断学]