注射用甲氧异腈中二氧硫脲的稳定性研究  

The study on stability of formamidinesulfinic acid in methoxy isobutyl isonitrile for injection

作　　者：沈勤炎[1] 黄群[1] 

机构地区：[1]江苏省原子医学研究所核医学国家重点实验室,无锡214063

出　　处：《核技术》1999年第5期263-267,共5页Nuclear Techniques

摘　　要：采用间接碘量法测定二氧硫脲（ＦＳＡ）的含量；进行ＦＳＡ的加速稳定性试验，考察湿度、强光对ＦＳＡ的影响，并结合药盒放射化学纯度的测定，推测注射用甲氧异睛（ＭＩＢＩ）的贮存有效期，提出保存药盒的理想条件。测得方法回收率为９８．０％－１０２．４％，ＦＳＡ的降解反应为一级反应，活化能为８４．５３ｋＪ／ｍｏｌ，药盒有效期为１３．７个月。In order to explore the optimal store condition and calculate the shelf life of methoxy isobutyl isonitrile (MIBI) for injection. The stability of formamidinesulfinic acid (FSA) in methoxy isobutyl isonitrile(MIBI) for injection was studied. FSA is determined by indirect iodometry analysis. The recovery was 98.0%-102.4%. Temperature and light are the major influence factors. Acceleration test showed that the degradation reaction was a first-order reaction. The activation energy E was 84.53kJ/mol. It was estimated that the shelf life of MIBI for injection kept in refrigerator might be longer than 13.7 months.

关 键 词：注射用 甲氧异腈 间接碘量法 二氧硫脲 稳定性 

分 类 号：R817[医药卫生—影像医学与核医学] R981.9[医药卫生—放射医学]