一种改进的^(99m)TcN(NoEt)_2的标记方法及其生物分布  

An improved labelling method on ^(99m)TcN(NOEt)_2 and its biodistribution

作　　者：张俊波[1] 王学斌[1] 

机构地区：[1]北京师范大学,北京100875

出　　处：《核技术》1999年第5期268-270,共3页Nuclear Techniques

摘　　要：为获得具有再分布特性的新型中性心肌灌注显像剂，采用了以ＳｎＣｌ２·２Ｈ２Ｏ为还原剂，ＳＤＨ为Ｎ３－离子提供体，在室温下制备了［９９ｍＴｃＮ］２＋ｉｎｔ中间体，然后与ＮＯＥｔ发生配体交换反应得到标记率＞９０％的９９ｍＴｃＮ（ＮＯＥｔ）２配合物。小鼠体内生物分布实验表明９９ｍＴｃＮ（ＮＯＥｔ）２具有较高的心肌摄取，在注射后５ｍｉｎ时心／血、心／肝、心／肺比值分别为１０．４８、 ２．０７、 ０．７４，脑摄取量为４．４３％ＩＤ·ｇ－１，脑／血比值为１．１２。mTcN(NOEt)2 is prepared through a two step ligand-exchange reaction by using SnCl2 as reduction agent and SDH (succinyl dihydrazide) as a donor of nitride nitrogen atom (N3-) at room temperature. The labelling procedure is more convenient for clinical use. The radiochemical purity (RCP) of the product is over 90% by TLC. The biodistribution results in mice indicate that 99mTcN(NOEt)2 has high myocardial uptake. For 5 min post injection the heart-to-blood, heart-to-liver and heart-to-lung ratios are 10.48, 2.07 and 0.74, respectively. The uptake of brain is also good. For 5min post injection the brain uptake is 4.43%ID·g-1 and the brain-to-blood ratio is 1.12. Based on these results 99mTcN(NOEt)2 exhibits prommising properties for further studies.

关 键 词：心肌摄取 生物分布 室温标记 心肌显像剂 锝99 

分 类 号：R817[医药卫生—影像医学与核医学] R981.9[医药卫生—放射医学]