糖尿病肾动态显像及与骨密度变化关系的临床研究  

A clinical study of relationship between dynamic renography and bone mineral density in patients with DM

作　　者：陈文新[1] 董惟誉[1] 何品玉[1] 刘用华[1] 刘玉珍[1] 

机构地区：[1]福建省立医院,福州350001

出　　处：《核技术》1999年第5期280-282,共3页Nuclear Techniques

摘　　要：对４７例糖尿病（ＤＭ）患者及３５例性别、年龄相当的正常对照者行９９ｍＴｃ－ＤＴＰＡ动态显像和双能Ｘ线法腰椎２—４骨密度测定。结果表明，肾功能轻度与重度受损的患者骨密度（ＢＭＤ）同龄百分比值低于对照组（Ｐ＜０．０５和Ｐ＜０．０１）。重度肾功能受损的ＤＭ患者中，ＢＭＤ减低较其他ＤＭ患者严重，提示严重糖尿病肾脏病变将导致骨质疏松。因此，对肾功能受损的ＤＭ患者进行骨质疏松的防治非常必要，同时保护ＤＭ患者的肾功能也将是预防骨质疏松的有效方法。The 99mTc-DTPA dynamic renography was performed in 35 normal controls and 47 patients with DM. Dual energy X-ray absorptiometry (DEXA) was used to estimate bone mineral density in L2-L4 for all of the cases. The results showed that BMD age-matched values of subgroups with mild or severe decreasing renal function were significantly lower than that of the controls (P<0.05 and P<0.01, respectively). And, BMD decreased more significantly for the subgroup with severe decreased renal function. Therefore, the prophalaxis of osteoporosis for DM patients with renal insufficiency is very important, and the protection of renal function of DM patients is effective for the prevention of diabetic osteoporosis.

关 键 词：糖尿病 肾动态显像 骨密度 临床研究 锝DTPA 

分 类 号：R587.1[医药卫生—内分泌] R817.47[医药卫生—内科学]