肺表面活性蛋白及其基因多态性与呼吸道合胞病毒感染研究进展  

Progress on association of pulmonary surfactant protein and its gene polymorphism with respiratory syncytial virus infection

作　　者：刘素云[1] 董琳[1] 

机构地区：[1]温州医学院附属育英儿童医院呼吸科,325027

出　　处：《国际呼吸杂志》2010年第20期1242-1245,共4页International Journal of Respiration

摘　　要：呼吸道合胞病毒（RSV）是婴幼儿呼吸道感染常见病原,生命早期的RSV下呼吸道感染与其后的反复喘息及哮喘的危险性增加显著相关,然而其发病机制是复杂的,且很多方面尚不明确.有研究认为肺表面活性蛋白（SP）及其基因多态性与严重的RSV感染有关.SP包括SP-A、SP-B、SP-C、SP-D4种蛋白,它们存在多个等位基因和基因多态性位点.已有的研究发现SP-A、SP-B和SP-D蛋白及其基因多态性与严重的RSV感染相关.Respiratory syncytial virus （RSV） is a common pathogen of respiratory tract infections in infants. Lower respiratory tract RSV infection in early life is significantly associated with increased risk of subsequent repeated wheezing and asthma, but its pathogenesis is complex and unclear in many aspects.Some studies have shown that pulmonary surfactant protein （SP） and its gene polymorphism are associated with severe RSV infection. SP includes four kinds of proteins, such as SP-A, SP-B, SP-C and SP-D. They have more than one allele and gene polymorphism. Researches have found that SP-A,SP-B and SP-D proteins and their gene polymorphisms are associated with severe RSV infection.

关 键 词：肺表面活性蛋白 基因多态性 呼吸道合胞病毒 呼吸道感染 

分 类 号：R72[医药卫生—儿科]