^(99)Tc^m-CQDO和^(99)Tc^m-CQDO-MeB的小鼠体内分布和药代动力学比较  

COMPARISON OF BIODISTRIBUTION IN MICE AND PHARMACOKINETICS OF 99 Tc m CQDO WITH 99 Tc m CQDO MeB

作　　者：朱钧清[1] 罗世能[1] 吴春英[1] 纪书仁[1] 曹国宪[1] 周翔[1] 陈正平[1] 莫奕青 

机构地区：[1]江苏省原子医学研究所核医学国家重点实验室

出　　处：《同位素》1999年第1期10-13,共4页Journal of Isotopes

摘　　要：以氯化亚锡为还原剂制备了９９Ｔｃｍ－ＣＱＤＯ及其甲基硼酸加成物９９Ｔｃｍ－ＣＱＤＯ－ＭｅＢ，经萃取纯化，其放化纯度均＞９０％。小鼠体内分布表明，两者均能被小鼠心肌迅速摄取；９９Ｔｃｍ－ＣＱＤＯ的心肌清除快，１０ｍｉｎ时已清除至（５．８８±１．６６）％ＩＤ／ｇ；而９９Ｔｃｍ－ＣＱＤＯ－ＭｅＢ在心肌内却有较长的滞留时间，６０ｍｉｎ时心肌摄取仍有（７．４２±０．１７）％ＩＤ／ｇ。两者在血中清除均符合双指数二室模型，Ｔ１／２α分别为１．３８ｍｉｎ和１．５１ｍｉｎ。ｐＨ为７．４０时。Tc m CQDO and its adduct of methaneboronic acid 99 Tc m CQDO MeB are prepared by the reduction of SnCl 2·2H 2O with Na 99 Tc mO 4. The radiochemical purity of 99 Tc m CQDO and 99 Tc m CQDO MeB are higher than 90%\ after being purified by extration. The biodistribution of 99 Tc m CQDO and 99 Tc m CQDO MeB in mice demonstrate that both of them can be easily absorbed by myocardium. 99 Tc m CQDO shows rapid clearence in myocardial issue and its uptake is only (5.88±1.66)% ID/g in 10 min postinjection. However, 99 Tc m CQDO MeB has longer retention in heart muscle and its uptake is (7.42±0.17)% ID/g in 60 min postinjection. The elimination of each from blood accords with a biexponential pattern. The first T 1/2 is 1.38 min and 1.51 min, respectively. The partition coefficient of 99 Tc m CQDO and 99 Tc m CQDO MeB are 25 and 12 respectively at pH7.40.

关 键 词：CQDO MeB 药代动力学 锝99 小鼠体内分布 显像剂 

分 类 号：R817.42[医药卫生—影像医学与核医学] R981.9[医药卫生—放射医学]