EDTA交换法制备脑灌注显像剂^(99)Tc^m-ECD——反应条件研究  

PREPARATION OF BRAIN PERFUSION IMAGING AGENT 99 Tc m ECD WITH EDTA EXCHANGE REACTION STUDY ON THE REACTION CONDITIONS

作　　者：贾少微[1,2] 朱霖[1,2] 

机构地区：[1]暨南大学医学院附属第二医院 [2]国家标准物质研究中心

出　　处：《同位素》1999年第1期33-38,共6页Journal of Isotopes

摘　　要：用脂溶性分数和放射化学纯度两项指标，系统地观察了以ＥＤＴＡ作为交换配体（转移敖虫合剂）时，制备脑灌注显像剂９９Ｔｃｍ－ＥＣＤ制剂的反应条件及其稳定性。结果表明，用ＥＤＴＡ交换法标记９９Ｔｃｍ－ＥＣＤ时，放射性浓度对标记影响不大，ｐＨ５～８范围宽，容易标记，ＥＤＴＡ用量为３６０μｇ和反应体积在２～６ｍＬ为宜；９９Ｔｃｍ－ＥＣＤ在不同ｐＨ的溶液中可稳定保存。In order to improve ECD kit formulation and select the best labeling condition, the radiochemical purity and lipophilic fraction of 99 Tc m ECD in different labeling conditions are observed. The results show that 99 Tc m ECD prepared by EDTA ligand exchange reaction is very stable, the radioactivity doesn ,t influence the radiochemical purity and lipophilic fraction, the best pH limits is ranged from 5 to 8, and 360 μg EDTA amounts with 2～6 mL volume is suitable. 99 Tc m ECD can reserve stably in different pH buffer solutions.

关 键 词：EDTA 反应条件 脑灌注 显像剂 锝99 ECD 

分 类 号：R817[医药卫生—影像医学与核医学] R981.9[医药卫生—放射医学]