药物缓释材料聚(乳酸-赖氨酸)的直接法合成与表征  

Direct synthesis and characterization of drug carrier material poly(lactic acid-co-lysine)

作　　者：叶瑞荣[1] 汪朝阳[1] 罗时荷[1] 毛超旭[1] 

机构地区：[1]华南师范大学化学与环境学院化学系,广州510006

出　　处：《化工新型材料》2010年第10期43-46,共4页New Chemical Materials

基　　金：国家自然科学基金(No.20772035)资助项目;广东省自然科学基金(No.5300082)

摘　　要：直接以廉价的外消旋乳酸(D,L-LA)和赖氨酸(Lys)为原料,采用熔融聚合法合成药物缓释材料聚(乳酸-赖氨酸)共聚物[P(LA-co-Lys)]。用特性黏度[η]、FTIR1、H-NMR、GPC、DSC、XRD等手段对P(LA-co-Lys)进行了系统表征,探讨了催化剂种类和用量、熔融聚合反应时间、反应温度以及不同投料比对聚合物合成的影响。当单体乳酸和赖氨酸投料摩尔比为90/10,在160℃、70Pa、催化剂SnCl2的用量0.5%的条件下熔融聚合8h时,聚合物重均相对分子质量(Mw)可达6200。随着赖氨酸投料量的增加,共聚物Mw和玻璃化转变温度(Tg)逐渐降低,且共聚物均为无定形态,能满足药物缓释材料的要求。Using cheap D,L-lactic acid（D,L-LA） and lysine（Lys） as starting monomer material,drug carrier material poly（lactic acid-co-lysine） [P（LA-co-Lys）] was synthesized via melt polycondensation.The copolymer was systematically characterized with intrinsic viscosity [η],FTIR,1H NMR,GPC,DSC and XRD.The influences of different synthetic conditions,including kinds and quantity of catalyst,time and temperature of melt copolycondensation,and different molar feed ratio on the polymer were discussed in detail.Under the conditions of molar feed ratio of LA/Lys 91/10,amount of catalyst SnCl2 0.5%,copolymerization temperature 160℃ and time 8h,pressure 70Pa,the copolymerization gave the polymer with maximum Mw 6200.With the increase of the molar feed ratio of Lys,Mw and Tg of the copolymer decreased gradually,and all copolymers were amorphous,which could meet the requirement for the application in drug delivery.

关 键 词：外消旋乳酸 聚乳酸 药物缓释材料 熔融聚合 

分 类 号：TQ460.6[化学工程—制药化工]