鱼腥草及新鱼腥草素钠注射剂在大鼠体内的“网通性”代谢规律研究  

In vivo Studies on Metabolic Network Compatibility of Herba Houttuyniae Injection and Sodium Neohouttuynin Injection in Rats

作　　者：邱云[1] 贺福元[1,2] 龚力民[1] 黄胜[1] 邹欢[1] 陈锋[1] 罗杰英[1] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208 [2]中南大学临床药理研究所,湖南长沙410078

出　　处：《中药材》2010年第9期1428-1433,共6页Journal of Chinese Medicinal Materials

基　　金：国家自然科学基金资助项目(81073142;30572378);中国博士后基金资助项目(20070410997)

摘　　要：目的:研究鱼腥草及新鱼腥草素钠2种注射剂在大鼠体内的代谢规律。方法:采用GC-MS测定大鼠静脉注射及口服鱼腥草(多成分)及新鱼腥草素钠(单成分)2种注射剂血浆和尿液中代谢产物,验证"网通性"代谢规律。结果:大鼠分别静注鱼腥草和新鱼腥草素钠注射剂后,血浆中检测出8种共同代谢产物,而尿液中检出39种;口服给药后,血浆中检测出16种共同代谢产物,而尿液中检出12种。鱼腥草注射剂经静注和口服2种不同给药形式后,血浆和尿液中分别检测出9和11种共同代谢产物,而新鱼腥草素钠注射剂分别检出8和17种。结论:鱼腥草及新鱼腥草素钠2种注射剂静注与口服后,在大鼠体内的代谢产物相同或相似,与原制剂挥发油成分结构类型相同,代谢途径相同。中药成分在生物体内代谢存在"网通性"。Objective：To study metabolic rule in rats for heartleaf houttuynia herb injection and Sodium New Houttuyfonate injection.Methods：The GC-MS was used to determine metabolites in plasma and urine of rats after intravenous and oral administration of heartleaf houttuynia herb injection as multi-component and Sodium New Houttuyfonate injection as single component.Results：For rats 8 common metabolites were determined in plasma after intravenous administration of heartleaf houttuynia herb injection and Sodium New Houttuyfonate injection,meanwhile 39 in urine.The 16 common metabolites were determined in plasma after oral administration,and 12 in urine.The 9 and 11 of same metabolites were determined in plasma and urine respectively after intravenous and oral administration of heartleaf houttuynia herb injection,8 and 17 common metabolites for Sodium New Houttuyfonate injection.Conclusion：The metabolites of heartleaf houttuynia herb and Sodium New Houttuyfonate injection in rats are the same or similar after intravenous and oral administration,and there are the same structure types between metabolites and original constituents of preparations.The metbolic pathways of the two preparations in rats are the same.There is metabolic Network Compatibility in organism between multi-components,single components and different administration forms for traditional Chinese medicine.

关 键 词：鱼腥草注射剂 新鱼腥草素钠注射剂 代谢产物 GC-MS 网通性 

分 类 号：R285.5[医药卫生—中药学]