川芎嗪衍生物TBN对家兔血小板聚集性的影响  

Inhibitory Effect of TBN on Platelet Aggregation in Rabbit

作　　者：许长林[1] 单璐琛[1] 孙业伟[1] 王玉强[1] 

机构地区：[1]暨南大学新药研究所,广东广州510632

出　　处：《中药材》2010年第9期1450-1453,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:观察川芎嗪衍生物TBN体内、外对家兔血小板聚集的影响,并与其母核结构川芎嗪(TMP)相比较。方法:利用二磷酸腺苷(ADP)、血小板活化因子(PAF)及花生四烯酸(AA)诱导家兔血小板聚集,采用Born氏比浊法,测定5 min血小板最大聚集率。观察给予TBN后血小板聚集率的变化,并与TMP相比较。结果:川芎嗪衍生物TBN体内、外均能显著降低由ADP、PAF及AA诱导的5 min血小板最大聚集率,作用强于其母核结构川芎嗪;体内作用与阿司匹林相当。结论:川芎嗪衍生物TBN具有较强的抗ADP、PAF及AA诱导的血小板聚集作用,其作用强于其母核结构川芎嗪。Objective： To investigate the inhibitory effect of TBN on rabbit platelet aggregation in vitro and in vivo,and cimpare with tetramethylpyrazine（TMP）.Methods：To seek out the maximum of platelet aggregation（expressed in percentage） within 5 minutes which was induced by ADP,PAF and AA according to the Born turbidimetric method with a Platelet-Aggregometer.Results：TBN significantly inhibited platelet aggregation induced by ADP,PAF and AA both in vitro and in vivo.TBN was more active than TMP.Conclusion：TBN has significant activity inhibiting platelet aggregation induced by ADP,PAF and AA in vitro and in vivo.

关 键 词：TBN TMP 血小板聚集 ADP PAF AA 

分 类 号：R285.5[医药卫生—中药学]