One-pot synthesis of tri- and tetra-substituted imidazoles using sodium dihydrogen phosphate under solvent-free conditions  

作　　者：Zahed Karimi-Jaberi Mohammad Barekat 

机构地区：[1]Department of Chemistry,Islamic Azad University

出　　处：《Chinese Chemical Letters》2010年第10期1183-1186,共4页中国化学快报（英文版）

摘　　要：Sodium dihydrogen phosphate （NaH2PO4） efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra-substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH2PO4.Sodium dihydrogen phosphate （NaH2PO4） efficiently catalyzes the condensation reaction of benzil, aldehydes, amines and ammonium acetate in a four-component reaction under solvent-free conditions. The reaction proceeds rapidly and affords the corresponding tetra-substituted imidazoles in high yields. Also an efficient route was developed for the synthesis of tri-substituted imidazoles from condensation of benzil, aldehydes and ammonium acetate using NaH2PO4.

关 键 词：Sodium dihydrogen phosphate IMIDAZOLES BENZIL SOLVENT-FREE 

分 类 号：O614.112[理学—无机化学]