Synthesis and characterization of biodegradable amphiphilic PEG-grafted poly(DTC-co-CL)  

作　　者：Qiu Jin Zhang Wei Pu Zhu Zhi Quan Shen 

机构地区：[1]MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China

出　　处：《Chinese Chemical Letters》2010年第10期1255-1258,共4页中国化学快报（英文版）

基　　金：financial supports from the National Natural Science Foundation of China(No. 20704036);special fund from the Major State Basic Research Project(No.2005CB623802);the Committee of Science and Technology of Zhejiang Province

摘　　要：A novel biodegradable copolymer, poly（5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone） （poly（DBTC-co-CL）） with pendant bromine groups, was synthesized via ring-opening polymerization （ROP） of ε-caprolactone （CL） and 5,5- dibromomethyltrimethylene carbonate （DBTC） using stannous octoate （Sn（Oct）2） as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted ＂click＂ reaction with alkyne-terminated polyethylene （A-PEG） by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly（DTC-co-CL）-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance （NMR） and size-exclusion chromatography （SEC）.A novel biodegradable copolymer, poly（5,5-dibromomethyltrimethylene carbonate-co-ε-caprolactone） （poly（DBTC-co-CL）） with pendant bromine groups, was synthesized via ring-opening polymerization （ROP） of ε-caprolactone （CL） and 5,5- dibromomethyltrimethylene carbonate （DBTC） using stannous octoate （Sn（Oct）2） as catalyst. Then the pendant bromine groups were completely converted into azide form, which permitted ＂click＂ reaction with alkyne-terminated polyethylene （A-PEG） by Huisgen 1,3-dipolar cycloadditions preparing biodegradable amphiphilic poly（DTC-co-CL）-g-PEG graft copolymer. The graft copolymer was characterized by nuclear magnetic resonance （NMR） and size-exclusion chromatography （SEC）.

关 键 词：POLYCARBONATE ＂Click＂ reaction Graft copolymer Ring-opening polymerization 

分 类 号：O632.31[理学—高分子化学] TQ326.9[理学—化学]