血清新蝶呤水平与不稳定型心绞痛病变的关系  

Expression and significance of neopterin in patients with unstable angina

作　　者：陈学军[1,2] 马根山[3] 

机构地区：[1]长江大学临床医学院内科教研室 [2]长江大学附属第一医院,湖北荆州434000 [3]东南大学附属中大医院心内科,江苏南京210009

出　　处：《现代医学》2010年第5期505-506,共2页Modern Medical Journal

摘　　要：目的:探讨冠心病患者血清新蝶呤与不稳定型心绞痛病变的关系。方法:采用酶联免疫吸附法检测61例不稳定型心绞痛患者(UA组)、41例稳定型心绞痛患者(SA组)和31名健康人(对照组)血清新蝶呤水平,根据冠状动脉造影结果计算复杂狭窄病变数目。结果:UA组血清新蝶呤水平显著高于SA组和对照组(均P<0.05),且血清新蝶呤水平与冠脉复杂病变数目成正相关(r=0.359,P<0.01)。结论:血清新蝶呤水平可作为为预测冠脉不稳定斑块活动性的无创性指标。Objective： To investigate the relationship between serum levels of neopterin and unstable plaque of coronary artery disease.Methods： Enzyme-linked immunosorbent assay was used to measure the serum levels of neopterin in 61 patients with unstable angina,41 patients with stable angina and 31 patients as controls.The number of coronary complex stenosis was assessed by coronary angiography.Results： The serum concentrations of neopterin was significantly increased in patients with unstable angina relative to those stable angina and controls（all P0.05）.Moreover,serum levels of neopterin in patients with unstable angina was positively correlated with the number of coronary complex stenosis（r=0.359）.Conclusion： Serum levels of neopterin may be new biomarkers to predict the activation of unstable plaque of coronary artery disease.

关 键 词：炎症 冠状动脉疾病 新蝶呤 

分 类 号：R541.4[医药卫生—心血管疾病]