转录核因子-KB在肝炎病毒相关性肿瘤中的研究进展  

Research advances in the relationship between nuclear factor-kappa B and hepatitis virus-associated cancers

作　　者：刘勇刚(综述)[1] 陈汝福(审校)[1] 李志花(审校)[1] 

机构地区：[1]中山大学孙逸仙纪念医院肿瘤科,广州510120

出　　处：《国际肿瘤学杂志》2010年第10期768-770,共3页Journal of International Oncology

摘　　要：转录核因子-KB（NF-KB）是炎症相关性肿瘤的重要调节基因，持续激活的NF-KB参与肝炎病毒相关性肿瘤（肝癌、胆管癌）的发生发展过程。抑制NF—KB的活性能有效延缓或阻碍肿瘤细胞的生长与转移，并能改善肿瘤对化疗的敏感性。因此，NF—KB有望在将来成为肝炎病毒相关性肿瘤治疗的有效靶点之一。NF-KB is a key regulator in inflammation-associated tumors. Constitutively activated NF-KB participates in the development of many hepatitis virus-associated cancers （hiopatocellular carcinoma, eholangio- carcinoma）. Inhibition of NF-KB＇s activity can effectively slow or stop cancer growth and metastasis and en- hance cancer cells＇ sensitivity to chemotherapy. Thus, NF-KB may become an effective therapeutic target in hepatitis virus-associated cancers in the near future.

关 键 词：NF—KB 肿瘤 肝炎病毒 

分 类 号：R556.502[医药卫生—血液循环系统疾病]