Novel findings in intermediary metabolism regulation  

作　　者：WANG QiJun ZHAO ShiMin 

机构地区：[1]Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China [2]State Key Laboratory of Genetic Engineering, Department of Microbiology, School of Life Sciences and Institute of Biomedical Sciences, Fudan University, Shanghai 200032, China

出　　处：《Chinese Science Bulletin》2010年第29期3231-3234,共4页

基　　金：supported by National Natural Science Foundation of China (30971485/C0706);Key Basic Research Project of Shanghai Municipal (JC20081400900)

摘　　要：Recent developments in intermediary metabolic research show us that our understanding of intermediary metabolism is not even nearly close to completion.Acetylation is emerging as a major regulatory mechanism for metabolism,joining the well-known mechanisms of transcriptional regulation,feedback inhibition,allosteric regulation and phosphorylation.Direct and indirect evidence has shown that acetylation of metabolic enzymes causes various changes,ranging from inhibiting and activating catalytic activity to affecting protein stability.Acetylation may also play a universal role in coordinating enzyme activity within a pathway,or metabolic flux among pathways.Another finding that has put intermediary metabolism into focus is that certain metabolites play indispensable roles in cell signaling.Unbalanced accumulation of 2-hydroxylglutarate or decrease in α-ketoglutarate significantly affects a family of proteins called dioxygenases,alters tumor-related hypoxia-inducible factor pathways,and is possibly involved in histone methylation.These new observations have raised broad interest in the scientific community,due to the close connections between metabolism and human diseases.Recent developments in intermediary metabolic research show us that our understanding of intermediary metabolism is not even nearly close to completion. Acetylation is emerging as a major regulatory mechanism for metabolism, joining the well-known mechanisms of transcriptional regulation, feedback inhibition, allosteric regulation and phosphorylation. Direct and indirect evidence has shown that acetylation of metabolic enzymes causes various changes, ranging from inhibiting and activating catalytic activity to affecting protein stability. Acetylation may also play a universal role in coordinating enzyme activity within a pathway, or metabolic flux among pathways. Another finding that has put intermediary metabolism into focus is that certain metabolites play indispensable roles in cell signaling. Unbalanced accumulation of 2-hydroxylglutarate or decrease in a-ketoglutarate significantly affects a family of proteins called dioxygenases, alters tumor-related hypoxia-inducible factor pathways, and is possibly involved in histone methylation. These new observations have raised broad interest in the scientific community, due to the close connections between metabolism and human diseases.

关 键 词：代谢调控 低氧诱导因子 组蛋白甲基化 中间代谢 监管机制 催化活性 乙酰化 转录调控 

分 类 号：Q591[生物学—生物化学] Q959.836