齐墩果酸滴丸的制备及质量评价  

Preparation and quality evaluation of oleanolic acid drop pills

作　　者：田燕[1] 高萌[1] 蒋妮 傅昌龙[3] 周欢欢[3] 明从坤[3] 田舸[1] 

机构地区：[1]大连医科大学药学院,辽宁大连116044 [2]大连儿童医院药剂科,辽宁大连116001 [3]大连医科大学,七年制辽宁大连116044

出　　处：《大连医科大学学报》2010年第5期521-523,538,共4页Journal of Dalian Medical University

摘　　要：[目的]制备齐墩果酸滴丸并测定其溶出度。[方法]按常规方法制备滴丸,采用RP-HPLC法,色谱柱为HYPERSIL C18柱,用甲醇∶0.03%醋酸水溶液（90∶10）为流动相,检测波长为210 nm处测定自制齐墩果酸滴丸的含量和溶出度。[结果]制得的滴丸大小均匀、圆整光滑、硬度适中。齐墩果酸的检测浓度在10-160μg/mL范围内与吸光度呈良好线性关系（r=0.9992）,含药量为5.09%（RSD=2.17%）。齐墩果酸滴丸30 min时溶出度为（85.2±1.04）%。[结论]该制备方法简单,滴丸成形性好,质量可控,体外溶出度高。【Objective】 To prepare oleanolic acid（OA） drop pills and evaluate their quality.【Methods】 The drop pills were prepared by a routine method.The content of OA and the dissolution rates of OA drop pills were determined by RP-HPLC on HYPERSIL C18 column（4.6 mm×250 mm,5 μm） with methanol-0.03% HOAc solution（90∶10） as the mobile phase,and the detective wavelength was 210 nm.【Results】 The drop pills were well-distributed in size,smooth and glossy in appearance,mild in hardness.The line arrange for OA was 10～160 μg/mL（r=0.9992）,with the content was 5.09%（RSD=1.27%）.The dissolution rate of OA drop pills was（85.2±1.04）% at 30 minutes.【Conclusion】 The prepared method of OA drop pills is simple,and the drop pills are well-shaped with controllable quality and high dissolution rate.

关 键 词：齐墩果酸 滴丸 RP-HPLC法 质量 

分 类 号：R286[医药卫生—中药学]