NF-κBp50、COX-2基因蛋白在尖锐湿疣组织中的表达及意义  

The expression and significance of NF-κBp50 and COX-2 in condyloma acuminatum

作　　者：张跃进[1] 陈向敏[2] 夏克栋[3] 董海艳[3] 陈韶[3] 

机构地区：[1]温州医学院诊断学教研室,浙江温州325035 [2]温州医学院生物学实验教学中心,浙江温州325035 [3]温州医学院微生物学与免疫学教研室,浙江温州325035

出　　处：《温州医学院学报》2010年第5期475-477,共3页Journal of Wenzhou Medical College

基　　金：温州市科技局科研基金资助项目(S2001A30)

摘　　要：目的:探讨核因子-κBp50(NF-κBp50)、环氧合酶-2(COX-2)基因蛋白在尖锐湿疣(condyloma acuminatum,CA)组织中的表达及意义。方法:采用免疫组化SP法对49例CA组织和26例正常宫颈组织进行NF-κBp50、COX-2蛋白检测。结果:NF-κBp50、COX-2基因蛋白在CA组织中的表达率分别为65.3%和61.2%,显著高于正常对照组(P<0.01)。CA组织中NF-κBp50和COX-2之间存在明显的正相关(rs=0.714,P<0.01)。结论:NF-κBp50、COX-2基因蛋白在CA组织中有过表达现象,提示NF-κBp50信号途径在CA发病和发展中可能起重要作用。Objective：To explore the expressions and their significance of NF-κBp50 and COX-2 in the tissues of Condyloma Acuminatum（CA）.Methods：The expressions of NF-κBp50 and COX-2 were measured with immuohistochemical staining technique in 49 cases of CA and 26 specimens of normal cervical tissue.Results：The expressive rates of NF-κBp50 and COX-2 in CA were 65.3% and 61.2% respectively,with the expressions of NF-κBp50 and COX-2 highly correlated（rs =0.714,P〈0.01）.The expressive rates of NFκ-Bp50 and COX-2 in CA were significantly higher than that in normal cervical tissue（P〈0.01）.Conclusion：There are an overexpression phenomena of NF-κBp50 and COX-2 in CA.It is suggested that the NF-κBp50 signal pathway may play an important role in the pathogenesis of CA.

关 键 词：NF-ΚB 核因子-κBp50 环氧合酶-2 尖锐湿疣 免疫组织化学 

分 类 号：R752.5[医药卫生—皮肤病学与性病学]