切除卵巢引起骨质疏松和血清二甲基精氨酸水平变化的研究  

Changes of serum asymmetric dimethyl arginine level in osteoporosis rats induced by ovariectomy

作　　者：庞炜 付友兰 康乐 于小迪 吕兵[2] 

机构地区：[1]解放军323医院骨科,陕西西安710054 [2]西安邮电学院体育部

出　　处：《西北国防医学杂志》2010年第5期324-326,共3页Medical Journal of National Defending Forces in Northwest China

基　　金：全军医药卫生科研基金课题资助项目(02M021)

摘　　要：目的:探讨雌激素对骨质疏松及血清不对称二甲基精氨酸(ADMA)的影响。方法:75只雌性SD大鼠随机分为卵巢切除组(OVX组)、卵巢切除及雌二醇治疗组(OVX+E2组)、假手术组(Sham组)。12周后,高效液相色谱法检测大鼠血清中ADMA含量,显微镜观察下肢骨形态学变化。结果:OVX组大鼠骨质疏松明显,OVX+E2组骨质疏松轻微,Sham组未发生骨质疏松。OVX组血清ADMA含量高于OVX+E2组和Sham组(P<0.05),OVX+E2组和Sham组间没有差异(P>0.05)。结论:卵巢切除后可造成骨质疏松及内源性ADMA水平的升高,雌激素治疗可抑制其变化。Objective：To explore the effect of estrogen on the osteoporosis and serum asymmetric dimethyl arginine（ADMA）.Methods：A total of 75 Sprague-Dawley rats were randomly divided into 3 groups：OVX group（ovariectomy）,OVX＋E2 group（estradiol treatment after ovariectomy）and sham group（sham operation）.Twelve weeks later,the serum ADMA was detected by high performance liquid chromatography,and the morphology of bone of lower extremity was observed with microscope.Results：Obvious osteoporosis occurred in OVX group,mild osteoporosis existed in OVX＋E2 group,and no osteoporosis was observed in sham group.The serum ADMA level in OVX group was significantly higher than that in OVX＋E2 group and sham group（P0.05）,and there was no obvious difference in serum ADMA level between OVX＋E2 group and sham group（P0.05）.Conclusion：The ovariectomy can result in osteoporosis and increase endogenous ADMA levels,and the estrogen treatment can inhibit these effects.

关 键 词：骨质疏松症 不对称二甲基精氨酸 雌激素 卵巢切除术 

分 类 号：R580[医药卫生—内分泌]