18F-FDG PET/CT定位诊断异位分泌促肾上腺皮质激素肿瘤的价值  

The diagnostic value of 18F-FDG PET/CT in the localization of ectopic adrenocorticotrophic hormone-secreting tumors

作　　者：张敏[1] 徐昊平[1] 李彪[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院核医学科,200025

出　　处：《中华核医学杂志》2010年第5期329-332,共4页Chinese Journal of Nuclear Medicine

基　　金：基金项目：上海市重点学科建设项目（S30203）

摘　　要：目的 探讨18 F-脱氧葡萄糖（FDG）PET/CT定位诊断异位分泌促肾上腺皮质激素（ACTH）肿瘤的应用价值.方法 疑诊异位分泌ACTH患者共7例,其中男4例,女3例,年龄27～63岁.7例患者均根据临床症状、生化指标或岩下窦采血结果诊断为异位ACTH综合征,同时进行了头颅MR、胸腹部CT、腹部B超及18F-FDG PET/CT检查,以探查原发病灶,并对发现的病灶进行大小及最大标准摄取值（SUVmax）的测量.结果 7例患者中3例经18F-FDG PET/CT找到原发病灶,病灶大小分别为1.1 cm×1.0 cm、1.5 cm×1.1 cm、1.6 cm×1.5 cm,SUVmax值分别为9.4,6.4和12.0.随后对患者进行了肿瘤切除,病理检查结果分别为胸腺瘤、肺部类癌及纵隔类癌.原发灶检出率为3/7.结论 18F-FDG PET/CT在定位诊断异位分泌ACTH肿瘤中具有一定价值.Objective To investigate the diagnostic value of 18F-fluorodeoxyglucose （FDG） PET/CT in the localization of ectopic adrenocorticotrophic hormone （ ACTH）-secreting tumors. Methods Seven patients with ectopic ACTH syndrome （confirmed by clinical symptom, biochemical data or bilateral simultaneous inferior petrosal sinus sampling） were included, 4 males and 3 females with age ranged 27-63 years old.All patients were examined with head MR, chest and abdomen CT, abdomen ultrasonography, and whole body 18F-FDG PET/CT. Location, size, and the maximum standardized uptake value （SUVmax） of the tumor were measured. Results 18 F-FDG PET/CT detected three ectopic ACTH-secreting tumors with the sizes 1. 1 cm×1.0 cm （SUVmax =9.4）, 1.5 cm×1.1cm （SUVmax =6.4）, and 1.6 cm ×1.5 cm （SUVmax =12.0）. The pathological findings of the three tumors were thymoma, lung carcinoid, and mediastinal carcinoid respectively. Conclusion 18 F-FDG PET/CT may help the localization of ecto pic ACTH-secreting tumors .

关 键 词：神经内分泌瘤 促肾上腺皮质激素 体层摄影术 发射型计算机 体层摄影术 X线计算机 脱氧葡萄糖 

分 类 号：R686[医药卫生—骨科学]