血液储存过程中趋化因子和CD40L积累及影响  

Cumulation and Effect of Chemokines and CD40L During Blood Storage——Review

作　　者：李娅娜[1] 刘孟黎[1] 

机构地区：[1]陕西省血液中心,陕西西安710061

出　　处：《中国实验血液学杂志》2010年第5期1350-1353,共4页Journal of Experimental Hematology

摘　　要：趋化因子(chem okine,CK)是一类能吸引白细胞到炎症感染部位的可溶性活性多肽。CD40配体(CD40L)参与前炎症介质的合成。血液贮存期CK及CD40L的积累可以介导非溶血性输血反应、输血相关急性肺损伤(TRALI)和自身免疫性疾病。贮存前过滤白细胞可以防止白细胞源性CK的释放,但不能阻止血小板源性CK的积累。γ射线辐照或紫外线β照射能抑制血小板储存过程中细胞因子的升高,可以有效地预防血小板输注后的非溶血性发热反应。本文就近年来对血液储存期CK及CD40L积聚对输血的影响、采取预防措施等研究进展作一综述。Chemokine is a class of soluble active peptides that attract white blood cells to the inflammatory site.CD40 ligand（CD40L）involves in synthesis of proinflammatory mediators.Accumulation of chemokine and CD40L can induce non-hemolytic reaction after transfusion,transfusion-related acute lung injury（TRALI）and autoimmune disease during blood component storage.Pre-storage leucocyte deletion can prevent the release of leucocyte-derived chemokines,but not prevent the accumulation of platelet-derived chemokines.γ-irradiation or ultraviolet β irradiation is effective in preventing the increase of chemokines in the storage of platelet,thus prevents non-hemolytic febrile reaction after platelet transfusion.In this review,the recent advance in research of accumulation of chemokines and CD40L during blood component storage,and its effect on blood transfusion,as well as preventive measures are summarized.

关 键 词：趋化因子 CKR CD40L 血液贮存 血小板 

分 类 号：R331.143[医药卫生—人体生理学]