前S2抗原与HBVDNA及HBV血清标志物的关系分析  

The relationship between HBVDNA and HBV serum markers with Pre - S2 antigen

作　　者：王桂琦[1] 郭立峰[2] 崔专义[1] 张国栓[1] 左东明 

机构地区：[1]石家庄市第一医院外科,石家庄050011 [2]石家庄市第二医院检验科,石家庄050051

出　　处：《临床肝胆病杂志》2010年第5期503-504,共2页Journal of Clinical Hepatology

基　　金：石家庄市科技进步奖立项课题(04146953)

摘　　要：目的探讨乙型肝炎病毒前S2(Pre-S2)抗原与乙肝病毒血清标志物五项、乙肝病毒DNA之间的相关性及临床意义。方法用酶联免疫吸附试验对982例乙肝患者血清标志物和乙肝病毒Pre-S2抗原进行检测;并用荧光定量PCR法对其进行HBVDNA检测。对HBV血清标志物不同阳性血清学模式进行分组分析。结果在HBeAg阳性模式组中,乙肝病毒Pre-S2和HBVDNA的检出率高,平均为95.34%和97.8%。在HBeAg阴性模式组中,乙肝病毒Pre-S2和HBVDNA的检出率低,平均为39.7%和32.3%。在HBsAg、HBeAg均为阴性的模式中Pre-S2抗原为1.45%。结论 Pre-S2抗原与HBeAg和HBVDNA密切相关;Pre-S2抗原检测完善和补充了乙肝病毒血清标志物检测的不足。Objective To study the relationship between hepatitis B virus serum markers and hepatitis B virus DNA（HBV DNA） with hepatitis B virus Pre-S2 antigen（Pre-S2）.Methods Hepatitis B serum markers and Pre-S2 antigens were tested by enzyme-linked immunosorbent assay and HBV DNA was detected by fluorescent quantitative-PCR in 982 hepatitis B patients.Results The detection rates of Pre-S2 and HBVDNA in HBeAg-positive and negative groups were 95.34% and 97.8%,and 39.7% and 32.3%,respectively.The detection rate of Pre-S2 antigen was 1.45% among HBsAg and HBeAg negative donors.Conclusion The Pre-S2 antigen is closely related with HBeAg and HBVDNA and the Pre-S2 antigen could be the complement to serum markers.

关 键 词：肝炎病毒 乙型 抗原 病毒 蛋白质前体 DNA 病毒 前S2抗原 

分 类 号：R512.62[医药卫生—内科学]