生精小管异位重构研究进展  

Recent development in ectopic reconstitution of seminiferous tubules

作　　者：刘平[1] 李铮[1] 薄隽杰[1] 

机构地区：[1]上海交通大学医学院附属仁济医院泌尿外科,上海市男科学研究所精子发育与遗传实验室,上海市人类精子库,上海200001

出　　处：《中华男科学杂志》2010年第10期928-932,共5页National Journal of Andrology

基　　金：上海市教委重点课题(10ZZ70);上海交通大学医学院科技基金(2008XJ017)~~

摘　　要：哺乳动物睾丸的形成和精子发生是一个复杂的过程,包括细胞的迁移、增殖、分化和细胞间的相互作用。尽管近年来对此进行了大量的研究,但对许多方面仍然是未知。缺少一个合适的研究睾丸形成与精子发生的模型是阻碍研究取得进展的一个重要原因。在过去的几年中,相继发现2种对研究哺乳动物精子发生很有价值的模型:一是未成熟的睾丸组织异位移植于免疫缺陷鼠的皮下可以成活并产生有功能的精子;另一是未成熟睾丸组织消化成单细胞后异位移植于免疫缺陷鼠的皮下可以重新形成生精小管样结构并完成完整的生精过程。本文对这两种方法的研究进展、应用及前景进行了综述。The testicular development and spermatogenesis of mammalians involve complex processes of cell migration,proliferation and differentiation and cell-cell interaction. In spite of extensive researches,many relevant aspects remain unclear. One of the impediments in the studies of testicular development and spermatogenesis of mammalians is the lack of a suitable model. In the last few years,two valuable models were developed for the study of mammalian spermatogenesis：testis tissue from immature animals transplanted ectopically into immunodeficient mice that could survive and produce functional spermatids,and isolated testis cells able to organize and rearrange into seminiferous cords that subsequently undergo complete spermatogenesis. This article presents an update and the applications and prospects of these two methods.

关 键 词：生精小管 异位重构 精子发生 

分 类 号：R698.2[医药卫生—泌尿科学]