夜间勃起功能监测结果与他达拉非治疗勃起功能障碍疗效的相关性研究  

Nocturnal penile tumescence and the effect of tadalafil on erectile dysfunction

作　　者：肖飞[1] 闫志安[1] 谷现恩[1] 白文俊[2] 王晓峰[2] 

机构地区：[1]北京市垂杨柳医院泌尿外科,北京100022 [2]北京大学人民医院泌尿外科,北京100044

出　　处：《中华男科学杂志》2010年第10期954-958,共5页National Journal of Andrology

摘　　要：目的:评价夜间勃起功能监测(NPT)结果与他达拉非疗效的相关性。方法:188例ED患者,根据NPT结果分为NPT正常组(n=136)和NPT异常组(n=52),2组患者均给予他达拉非治疗,3次/周,每次20mg。治疗前及治疗1个月后,分别评价IIEF-5评分、阴茎插入成功率(SEP2)、完成性交成功率(SEP3)以及总体评价问卷(GAQ),比较2组间治疗前后各项指标的变化。结果:2组患者用药后其IIEF-5评分、SEP2、SEP3均显著高于用药前(P<0.01)。NPT正常组患者治疗后的IIEF-5评分、SEP2、SEP3及GAQ均显著高于NPT异常组患者治疗后结果(P<0.05,P<0.01)。结论:经过他达拉非治疗1个月后,NPT正常组患者勃起功能(包括IIEF-5评分、SEP2及SEP3)较NPT异常组改善更为显著,即NPT正常组患者行他达拉非治疗疗效更佳。Objective：To explore the correlation between the results of the nocturnal penile tumescence （NPT） test and the efficacy of tadalafil in the treatment of ED. Methods：A total of 188 ED patients were divided into a normal NPT group （n = 136） and an abnormal NPT group （n = 52） according to the results of the NPT test. All of them were treated with tadalafil at 20 mg 3 times a week. The IIEF-5 score,SEP2,SEP3 and GAQ score were compared between the two groups before and 1 month after the treatment.Results：Tadalafil treatment significantly improved IIEF-5 score,SEP2 and SEP3 of both groups of the patients （P 0.01）. Compared with the abnormal NPT group,the normal NPT group showed a remarkable increase in the IIEF-5 score,SEP2,SEP3 （P 0.05） and GAQ score （P 0.01）. Conclusion：After 1 month of tadalafil treatment,the normal NPT group achieved a more significant improvement of erectile function and sexual satisfaction than the abnormal NPT group,suggesting that tadalafil has a better therapeutic effect for ED patients with normal NPT.

关 键 词：勃起功能障碍 夜间勃起功能监测 他达拉非 疗效 

分 类 号：R698.1[医药卫生—泌尿科学]