速度向量成像结合潘生丁负荷在糖尿病大鼠心肌收缩功能评价中的应用价值  

Value of velocity vector imaging and stress echocardiography in the assessment of systolic function of left ventricular in diabetic rats

作　　者：卫张蕊[1] 张军[2] 张海滨[2] 苏海砾[2] 施红[1] 

机构地区：[1]解放军第117医院特诊科,杭州310013 [2]第四军医大学西京医院超声科

出　　处：《中华超声影像学杂志》2010年第10期888-892,共5页Chinese Journal of Ultrasonography

基　　金：基金项目：国家自然科学基金（3087（）714）

摘　　要：目的 探讨速度向量成像（VVI）技术结合潘生丁负荷试验是否可以早期检测糖尿病（DM）大鼠左室壁潜在的心肌功能障碍.方法 雄性SD大鼠18只,腹腔注射链脲菌素复制DM模型,另12只体质量匹配的雄性SD大鼠腹腔注射等量柠檬酸缓冲液作为对照.分别在静息状态和潘生丁负荷后,对两组大鼠（12周）乳头肌水平左室短轴观行VVI及M型超声心动图检查,分别测量潘生丁负荷前后乳头肌水平左室短轴观各个节段心肌最大收缩速度（Vs）、切向应变（εc）、径向应变（εr）、收缩期最大切向应变率（SRc）、径向应变率（SRr）及室壁增厚率的平均值.处死动物,摘除心脏,行HE染色及透射电镜检查.结果 静息状态下,DM组SRc较对照组显著减低（P＜0.05）,其余指标与对照组的差异无统计学意义.潘生丁负荷后,DM组各指标均较对照组显著减低（P＜0.05）.而M型检测的两组间室壁增厚率的差异并无统计学意义（P＞0.05）.结论 VVI与负荷超声心动图相结合,可以更敏感地检测出DM大鼠潜在的室壁运动异常.SRc可能是更为敏感的指标,其在静息状态下便可以检测出这种室壁运动的异常.Objective To investigate whether velocity vector imaging （VVI） combined with stress echocardiography could detect potential myocardial impairment of the left ventricle（LV） in diabetic rats.Methods DM rats （ n = 18,administered by STZ at 65 mg/kg） and control rats（ n = 12） were performed with VVI and M-mode echocardiography both at rest and after dipyridamole stress 12 weeks later. Twodimensional echocardiographic cine loops and M-mode images of three consecutive beats were obtained from the short-axis views at the mid-LV level. The means of segmental peak systolic velocity（Vs）, circumferential strain（εc） ,radial strain（εr）, systolic circumferential and radial strain rate （SRc, SRr） and the percent wall thickening （WT% ,derived from M-mode） were obtained. After echocardiograms were performed,the hearts were excised and prepared for HE staining and ultrastructural observations under electron microscopy.Results At rest,only SRc in the DM group was significantly lower than that in the control group（ P 〈0.05）, the other parameters were statistically comparable between the two groups. After dipyridamole stress,all VVI values in the DM group were significantly lower than those in the control group （ P 〈0.05）.However,there was no significant difference in WT% between the two groups either at rest or after dipyridamole stress （ P 〉0.05）. Conclusions The VVI parameters combined with dipyridamole stress are more effective in evaluating potential myocardial impairment of the LV walls in diabetic rats. SRc might be more sensitive indices that can be used to detect myocardial impairment at rest.

关 键 词：超声心动描记术 压力 糖尿病 心室功能 左 双嘧达莫 速度向量成像 

分 类 号：R686[医药卫生—骨科学]