超声引导下犬自体血栓栓塞性急性肺动脉高压模型的建立及意义  

Establishment of a canine model with acute thrombo-embolic pulmonary hypertension guided by echocardiography

作　　者：孙丹丹[1] 陈洪茂[1] 段云友[1] 尚福军[2] 梁宁南[1] 曹玮[3] 刘禧[1] 曹铁生[1] 

机构地区：[1]第四军医大学唐都医院超声诊断科,西安710038 [2]第四军医大学唐都医院心内科,西安710038 [3]第四军医大学唐都医院介入科,西安710038

出　　处：《中华超声影像学杂志》2010年第10期893-896,共4页Chinese Journal of Ultrasonography

基　　金：基金项目：国家自然科学基金（30772057）

摘　　要：目的 探讨超声引导下建立肺动脉血栓栓塞所致犬急性肺动脉高压模型的可行性.方法 模拟人体急性肺动脉血栓栓塞的病理生理过程,建立肺动脉血栓栓塞所致的犬急性肺动脉高压模型.超声引导下经股静脉穿刺,放置右心导管监测肺动脉压力,同时对侧股静脉推注自体血栓,以肺动脉收缩压超过30 mmHg为模型建立成功的标准.结果 超声可以准确引导右心导管的放置.实验用犬27只,成功建立急性肺动脉高压模型24只,成功率88.9%.结论 超声引导下建立肺动脉血栓栓塞所致犬急性肺动脉高压模型的方法具有良好的可行性和可重复性.Objective To establish a canine model with acute thrombo-embolic pulmonary hypertension monitored by echocardiography. Methods Simulated the pathophysiologic process of acute thrombo-embolic pulmonary hypertension in human, the canine model was developed. The femoral vein puncture and the right heart catheterization to monitor pulmonary artery pressure were operated guided by echocardiography, while the autologous blood clot was injected to the contralateral femoral vein. The criteria of model was the pulmonary artery systolic pressure was higher than 30 mmHg. Results Echocardiography can accurately guide the placement of right heart catheterization and ancillarily observe the pressure testing of pulmonary artery. Of twenty seven healthy experiment dogs, twenty four models with acute thromboembolic pulmonary hypertension were successfully developed. The successful rate was 88.9 %. Conclusions This canine model with acute thrombo-embolic pulmonary hypertension guided by echocardiography is easy to operate and its repeatability is good.

关 键 词：超声检查 肺栓塞 高血压 肺性 

分 类 号：R686[医药卫生—骨科学]