HBV—LP检测HBVDNA复制的敏感性与特异性研究  

The study of the sensitive and specificity on HBV DNA replication by HBV-LP detecting

作　　者：单平囡 卢志勇 宣国红 翁利民 茹金城 谈素红 许德顺 

机构地区：[1]绍兴县中心医院暨中国医大绍兴医院检验科,浙江312030

出　　处：《中华实验和临床病毒学杂志》2010年第1期68-70,共3页Chinese Journal of Experimental and Clinical Virology

摘　　要：目的 检测乙肝患者的HBV-LP及HBV DNA,探讨HBV-LP的敏感性和特异性及其临床应用价值.方法 HBV-LP检测采用ELISA法,HBV DNA检测采用RT-PCR法.结果 HBV-LP检测及HBV DNA检测的敏感性分别为64.89%、99.68%和60.63%、100%（P〉0.05）;两检测的＋LR和-LR分别为202.78、60.63和0.3522、0.3937,＋LR之间差异有统计学意义（P〈0.005）.结论 HBV-LP检测有与HBV DNA检测相近的敏感性及特异性,阳性似然比更高于HBV DNA检测,为较好的检测HBV DNA复制的血清学指标.Objective To detect HBV-LP and HBV DNA of the patients with hepatitis B, and to study the sensitive and specificity of HBV-LP detecting and its evaluate on for clinical application. Methods The ELISA was used for HBV-LP detecting and RT-PCR for HBV DNA detecting. Results The sensitive and specificity of HBV-LP and HBV DNA were 64.89% ,99.68% ,60.63% and 100% respectively（P 〉 0.05）;＋LR, -LR were 202.78,60.63, 0.3522 and 0.3937, and there were significance between ＋LR of the detecting （P〈0.005 ）. Conclusion The sensitive and specificity of HBV-LP and HBV DNA detecting are considerable, ＋LRof HBV-LP are higher comparing HBV DNA. The HBV-LP is better serology index for detecting replication of HBV DNA.

关 键 词：肝炎表面抗原 乙型 肝炎病毒 乙肝 DNA 敏感性与特异性 

分 类 号：R512.62[医药卫生—内科学]