胰腺发育和胰腺癌中Notch信号通路作用的研究进展  

Progress in Role of Notch Signaling Pathway in Pancreas Development and Pancreatic Cancer

作　　者：杜潇[1] 赵玉沛[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院基本外科,北京100730

出　　处：《中国普外基础与临床杂志》2010年第10期1109-1112,共4页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨Notch信号通路在胰腺发育和胰腺癌发生、发展中所起的作用。方法复习国内、外相关文献并进行综述、分析。结果 Notch信号通路在胰腺早期发育中可能起着维持胰腺上皮细胞处于祖细胞状态,延迟其分化直至时机成熟的作用;Notch信号通路在胰腺癌的起始、发生及进展中均明显活化。结论 Notch信号通路在胰腺发育中起重要作用;持续激活的Notch信号通路促进了胰腺癌的发展,且可能为胰腺癌发生的始动因素之一。Objective To investigate the role of Notch signaling pathway in pancreas development and pancreatic cancer.Methods The related literatures were reviewed and analyzed.Results Notch signaling played a role early in development by maintaining pancreatic epithelial cells in a progenitor state and delaying their differentiation until timely appropriate.Notch signaling was reactivated in the initiation and progression of pancreatic cancer.Conclusion Notch signaling pathway plays an important role in the pancreas development.Sustained Notch signaling activity promotes the progression of pancreatic cancer,and may be one of major factors in the initiation of pancreatic cancer.

关 键 词：胰腺发育 胰腺癌 NOTCH信号通路 进展 

分 类 号：R322.491[医药卫生—人体解剖和组织胚胎学] R735.9[医药卫生—基础医学]