移居高原人返平原后甲状腺及胰腺β细胞功能观察  

Function Changes of Thyroid and Pancreatic β-cells of People Returning to Plain from Plateau

作　　者：袁振才[1] 张雪峰 张丽兴[1] 张雅鸿[1] 周琼[1] 周其全[3] 

机构地区：[1]中铁一局集团咸阳中心医院,陕西咸阳712000 [2]格尔木市人民医院,青海格尔木816000 [3]中国人民解放军第三军医大学,重庆400038

出　　处：《环境与健康杂志》2010年第9期804-807,共4页Journal of Environment and Health

摘　　要：目的了解移居高原人返平原后甲状腺及胰腺β细胞的功能状况。方法于2008年4—10月,选择参与青藏铁路施工且连续时间在6个月或以上的男性员工517人作为观察组,选择未参与青藏铁路施工且工作性质、年龄等因素与观察组大致相同的男性员工220人作为对照组,分别测定其总三碘甲腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺素(TSH)及空腹血糖(FPG)、空腹胰岛素(FINS)、餐后2h血糖(2hPG)、餐后2h胰岛素(2h-INS)等。结果观察组和对照组的甲状腺和胰腺β细胞检测指标均在正常范围内。观察组TT4、FT3均值高于对照组(P<0.01)。将年龄作为控制因素,TT3与施工海拔、高原居留时间呈负相关(P<0.05);TT4、FT3与施工海拔、高原居留时间呈正相关,与返平原时间呈负相关(P<0.01);FT4与施工海拔、高原居留时间呈正相关(P<0.05)。观察组FPG、2hPG均值小于对照组(P<0.05)。将体质指数(BMI)作为控制因素,FPG、2hPG与施工海拔呈负相关,FPG还与返回平原的时间呈正相关(P<0.05)。结论高原环境对人体甲状腺和胰腺β细胞功能无不良影响。Objective To understand the function changes of the thyroid and pancreatic β-cells of the people who returned to the plain from the plateau.Methods In April to October,2008,517 male workers were selected from Qinghai-Tibet railway construction project as the investigated group who worked on the plateau for more than 6 months and 220 male workers were also chosen as the control group who did not participate that project but having the same research factors as those in the investigated group,such as job category,labor intensity and age.TT3,TT4,FT3,FT4,TSH and FPG,2 h PG,FINS,2 h-INS were determined.Results All the test indexes were at the normal level,but the average values of TT4 and the FT3 in the investigated group were higher（P〈0.01） than those in the control group.Taking age as the control factor,TT3 was positively correlated（P〈0.05） with the elevation and the length of stay on plateau,and TT4 and FT3 were positively correlated with the two indexes,and they were negatively correlated with the length of period returning to plain.FT4 was positively correlated（P〈0.05） with the elevation and the length of stay on the plateau.Taking BMI as the control factor,FPG and 2 h PG were negatively correlated with the elevation,FPG was also positively correlated（P〈0.05） with the length of period returning to the plain.Conclusion The results of the present paper indicate that plateau environment has no significant adverse effects on the functions of human thyroid and pancreatic β cells

关 键 词：高海拔 甲状腺 胰腺 Β细胞 卫生调查 

分 类 号：R181.3[医药卫生—流行病学]