运动预适应心肌保护效应与细胞信号转导研究现状和展望  

Current Situation and Prospect of Researches on Cell Signaling Transduction in Cardioprotection of Exercise Preconditioning

作　　者：申毓军[1] 潘珊珊[1] 

机构地区：[1]上海体育学院运动科学学院,上海200438

出　　处：《上海体育学院学报》2010年第6期55-58,68,共5页Journal of Shanghai University of Sport

基　　金：上海市科委基金资助项目(09490503300);上海体育学院研究生教育创新基金资助项目(2009)

摘　　要：采用文献综述法,对运动预适应心肌保护效应的研究现状进行分析和总结,探讨运动预适应的心肌保护效应及其细胞信号转导途径。研究表明,运动预适应具有强大的心肌保护效应,其细胞信号转导途径可能为:内源性触发物质通过相应受体,活化蛋白激酶为主的中介物质,从而调控效应物质,改变离子通道通透性和相关蛋白酶活性,诱导应激蛋白生成,发挥心肌保护效应。Using the method of literature review, the present paper analyzed the researches on cardioprotective effect of exercise preconditioning （EP） and its mechanism. These studies indicate that EP has a powerful protective effect to the heart, and the cellular signaling transduction of the cardioprotection may progress as follows： the endogenous factors induced by EP trigger the cascade of signaling through their receptors, and activate the cytoplasmic mediators like protein kinases, then terminate on one or several end effectors, inducing ionic channels open, the activity of antioxidant enzymes increases and heat shock proteins generation, which finally prevents the heart from ischemia/ reperfusion injury.

关 键 词：运动预适应 心肌 缺血/再灌注 缺血预适应 信号转导 

分 类 号：G804.2[文化科学—运动人体科学]