日本七叶树化学成分的研究Ⅰ.七叶皂苷Ⅰa和Ⅰb的分离和鉴定  

Studies on the Chemical Constituents of Japanese Buckeye Seed (Aesculus turbinata) Ⅰ．Isolation and Identification of Escins Ⅰa and Ⅰb

作　　者：赵静[1] 杨秀伟[1] 

机构地区：[1]北京医科大学天然药物及仿生药物国家重点实验室,100083

出　　处：《中草药》1999年第5期327-332,共6页Chinese Traditional and Herbal Drugs

摘　　要：从日本七叶树 Ａｅｓｃｕｌｕｓ ｔｕｒｂｉｎａｔａ Ｂｌｕｍｅ．种子的 ７０％乙醇提取物中分得 ４个三萜皂苷化合物，经光谱学分析鉴定了其中 ２个化合物的结构，它们分别为：七叶皂苷Ⅰａ：２１β－巴豆酰基－２２ａ－乙酸基原七叶皂苷配基－３β－Ｏ－［β－Ｄ－吡喃葡萄糖基（１－２）］［β－Ｄ－吡喃葡萄糖基（１－４）］－β－Ｄ－吡喃葡萄糖醛酸（２１β－ｔｉｇｌｏｙｌ－２２α－ａｃｅｔｙｌｐｒｏｔｏａｅｓｃｉｇｅｎｉｎ－３β－Ｏ－［β－Ｄ－ｇｌｕｃｏｐｙｒａｎｏｓｙｌ（１－２）］［β－Ｄ－ｇｌｕｃｏｐｙｒａ－ｎｏｓｙｌ（１－４）］－β－Ｄ－ｇｌｕｃｏｐｙｒａ－ｎｏｓｉｄｕｒｏｎｉｃ　ａｃｉｄ）和七叶皂苷Ⅰｂ：２１β－当归酰基－２２α－乙酰基原七叶皂苷配基－３β－Ｏ－［β－Ｄ－吡喃葡萄糖基（１－２）］［β－Ｄ－吡喃葡萄糖基（１－４）］－β－Ｄ－吡喃葡萄糖醛酸（２１β－ａｎ－ｇｅｌｏｖｌ－２２ａ－ａｃｅｔｙｌｐｒｏｔｏａｅｓｃｉｇｅｎｉｎ－３β－Ｏ－［β－Ｄ－ｇｌｕｃｏｎｙｒａｎｏｓｙｌ（１－２）］［β－Ｄ－ｇｌｕｃｏｐｙｒａｎｏｓｙｌ（ｌ－４）］－β－Ｄ－ｇｌｕｃｏｐｙｒａｎｏｓｉｄｕｒｏｎｉｃ ａｃｉｄ）。Four triterpenoid saponins were isolated from 70% ethanolic extract of the seeds of Aesculus turbinata B1.. Two of them were identified by spectroscopic and chemical methods as escin Ⅰa： 21β- tigloyl-22a-acetyl-protoaescige (1-2 )] [ β-D-glucopyranosyl (l-4 )]-β-D- glucopyranosiduronic acid, and escin Ⅰb： 21β-angeloyl-22α-acetylprotoaescigenin- 3β-O-[β-D-glucopyranosyl(1- 2)][β-D-glucopyranosyl (1-4)]-β-D-glucopyranosiduronic acid. Both were obtained from A. turbinata for the first time.

关 键 词：日本七叶树 七叶树科 三萜 七叶皂甙 化学成分 

分 类 号：R931.6[医药卫生—生药学]