低温预防周围神经缺血再灌注损伤的形态学研究  

Morphologic strdy of Prevention of Post-ischemia Reperfusion Injury to Peripheral Nerve with Experime ntal Hypothermia

作　　者：罗晓中[1] 安洪[2] 

机构地区：[1]四川省自贡市第四人民医院骨科,643000 [2]重庆医科大学附属第一医院骨科,400016

出　　处：《重庆医学》1999年第3期175-176,共2页Chongqing medicine

摘　　要：采用暂时阻断家兔髂总动脉起始处的血流的实验模型，观察用降温方法预防坐骨神经的缺血再灌注损伤（缺血４小时，再灌注５小时）的形态学变化，结果显示：神经的缺血再灌注损伤在低温下较常温下明显轻微，提示降温可预防周围神经缺血再灌注损伤。Model of post-ischemia reperfusion of unilateral sciatic nerve was produced in rabbits by temporary occluding the common iliac artery, with 4 hours of ischemia and 5 hours of reperfusion to achieve post-ischemia reperfusion injury of the nerve. Hypothemia as preventive method to post-ischemia reperfusion injury to the flerve was studied. and the morphologic change of specimens of the nerve was observed. We have demonstrated that the injury of the nerve was evidently milder under low temperature than that under room temperature. The result suggests that hypothemia can be used to prevent the post-ischemia reperfusion injury of peripheral nerve.

关 键 词：周围神经缺血 再灌注损伤 预防 低温 形态学研究 

分 类 号：R651.3[医药卫生—外科学]