TLSF_(JM)对同种异体抗原诱导的小鼠杀伤性T细胞分化及效应功能的影响  

The effect of TLSFJM on alloantigen induced differentiation and cytotoxicity of mouse CTL

作　　者：韩卫宁[1] 李德敏[1] 苏丽[1] 欧阳为明[1] 贾卫[1] 金伯泉[1] 

机构地区：[1]第四军医大学免疫学教研室,西安710032

出　　处：《细胞与分子免疫学杂志》1999年第2期118-120,共3页Chinese Journal of Cellular and Molecular Immunology

基　　金：国家自然科学基金

摘　　要：本文以小鼠混合淋巴细胞反应为模型，研究了ＪＭ 急性Ｔ 淋巴细胞白血病细胞分泌的抑制因子（ ＴＬＳＦＪＭ）在体外对同种异体抗原诱导小鼠Ｔ 细胞增殖和杀伤性Ｔ 细胞分化的影响。结果表明：（１） ＴＬＳＦＪＭ 可明显抑制同种异体抗原刺激的Ｔ 细胞增殖， 且具有剂量依赖性；（２） ＴＬＳＦＪＭ 能有效地抑制同种异体抗原诱导的小鼠ＣＴＬ 分化；（３）ＴＬＳＦＪＭ 对杀伤相ＣＴＬ 的杀伤活性没有抑制作用。The effect of TLSFJM on alloantigen induced differentiation and cytotoxicity of mouse CTL was investigated in vitro using mouse mixed lymphocyte reaction(MLR). The results showed that TLSFJM markedly suppressed alloantigen induced proliferation of T cells (82%of inhibition when 1%concentration of TLSFJM was added) and differentiation of CTL in a dose dependent manner but have no influence on the cyctotoxicity of CTL when TLSFJM was added in cytolytic phage.

关 键 词：抑制因子 CTL TLSFJM T细胞 分化 同种异体抗原 

分 类 号：R392.11[医药卫生—免疫学]