NO-cGMP信息通路在阿片类药物耐受和依赖中的调节作用  

The tolerance and dependence of opiate are modulated by NOcGMP signal pathway

作　　者：臧梦维[1,2] 刘景生[1,2] 

机构地区：[1]中国医学科学院基础医学研究所 [2]中国协和医科大学基础医学院药理室

出　　处：《中国药理学通报》1999年第2期106-111,共6页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金

摘　　要：ＮＯ合酶抑制剂能阻断或逆转μ、δ激动剂耐受和戒断反应，而对κ激动剂无明显作用，其药理效应类似于阿片成瘾治疗的常用药物可乐定。甲基兰抑制鸟苷酸环化酶活性，使ｃＧＭＰ生成减少，对阿片类药物耐受和戒断症状均有阻断作用，提示ＮＯｃＧＭＰ通路在阿片耐受和依赖发生中起重要作用，为寻找和设计治疗阿片类耐受成瘾的药物提供新的策略。Nitric oxide synthase (NOS) inhibitors can prevent or reverse the tolerance to and dependence on opioid agonists, but not those of agonists. Profile of these drugs for attenuating morphine withdrawal is similar to that of clonidine, a drug used clinically to treat opioid withdrawal. Even methylene blue (MB) which can inhibit guanylate cyclase activity, is also effective, presumably by blocking cGMP formation resulting from NO release. These results demonstrate that the NOcGMP pathway is of importance in development of opioid tolerance and dependence and provides new possibility in the design of agents counteracting with opioid tolerance and withdrawal.

关 键 词：一氧化氮合酶 阿片类药物 阿片成瘾 治疗 

分 类 号：R595.505[医药卫生—内科学] R971.2[医药卫生—临床医学]