5-羟色胺和环磷酸腺苷对睡眠的影响  

Effects of 5HT and cAMP in nucleus Amygdala on sleep in rats

作　　者：朱国庆[1] 钟明奎[1] 张景行[1] 越乐章 柯道平[1] 王敏[1] 施蕾[1] 

机构地区：[1]安徽医科大学生理学教研室

出　　处：《中国药理学通报》1999年第2期141-143,共3页Chinese Pharmacological Bulletin

基　　金：安徽省自然科学基金

摘　　要：目的研究杏仁核中５羟色胺（５ＨＴ）和环磷酸腺苷（ｃＡＭＰ）对大鼠睡眠的影响。方法多导睡眠描记和杏仁核微量注射。结果５ＨＴ前体５羟色氨酸（５ＨＴＰ）引起慢波睡眠、快波睡眠和总睡眠时间增多，入睡潜伏期缩短；５羟色胺受体阻断剂二甲麦角新碱（ＭＳ）对睡眠无直接影响，但可完全阻断５ＨＴＰ的促睡眠效应；ｃＡＭＰ可引起慢波睡眠和总睡眠时间延长，入睡潜伏期缩短。结论杏仁核参与睡眠觉醒调节，杏仁核中５ＨＴ和ｃＡＭＰ有明显的促睡眠效应。AIM To investigate the effects of serotonin (5HT) and cyclic adenosine monophosphate (cAMP) in amygdala microinjection. METHODS Polysomnography (PSG) and nucleus amygdala microinjection. RESULTS 5hydroxytryptaphan (5HTP),immediate procusor of 5HT, enhanced slow wave sleep (SWS), paradoxical sleep (PS) and total sleep time (TST), and shortened the latency of SWS. Metlysergide (MS), an antagonist of 5HT receptor, had no direct effect on sleep, but abolished sleeppromoting effect of 5HTP. Cyclic AMP increased SWS and TST, and the latency of SWS. CONCLUSION Nucleus amygdala plays an important role in regulating sleep,both 5HT and cAMP in nucleus amygdala have a sleeppromoting effect.

关 键 词：5-羟色胺 环磷酸腺苷 睡眠 杏仁核 

分 类 号：R971.3[医药卫生—药品]