伊曲康唑脂质体体外抗真菌作用研究  

In Vitro Antifungal Activity of Itraconazole Liposome

作　　者：纪宏宇[1,2] 魏华[3] 刘红梅[1,2] 唐景玲[4] 董迪[1] 宋笑丹[3] 吴琳华[1,2] 

机构地区：[1]哈尔滨医科大学附属第二医院药学部,哈尔滨市150086 [2]黑龙江省高校重点实验室,哈尔滨市150086 [3]哈尔滨医科大学附属第一医院药学部,哈尔滨市150001 [4]哈尔滨医科大学药学院,哈尔滨市150086

出　　处：《中国药房》2010年第41期3869-3871,共3页China Pharmacy

基　　金：黑龙江省科技厅重点课题(GB06C307)

摘　　要：目的:研究伊曲康唑脂质体体外抗深部真菌作用。方法:测定伊曲康唑脂质体对白色念珠菌、克柔念珠菌、光滑念珠菌、近平滑念珠菌、热带念珠菌等5种临床常用深部真菌的最小抑菌浓度(MIC)和最小杀菌浓度(MBC),采用平皿菌落计数法进行菌落计数,制备克柔念珠菌、近平滑念珠菌的菌落数-时间曲线,并与伊曲康唑注射液的结果进行比较。结果:与伊曲康唑注射液比较,伊曲康唑脂质体对5种深部真菌的MIC、MBC基本一致,对克柔念珠菌、近平滑念珠菌的菌落数-时间曲线基本一致。结论:伊曲康唑脂质体与伊曲康唑注射液对5种深部真菌具有相似的体外抗真菌作用。OBJECTIVE：To study the antifungal activity of Itraconazole liposome in vitro.METHODS：The minimal inhibitory concentration（MIC） and the minimal bactericidal concentration（MBC） of Itraconazole liposome against 5 kinds of deep fungus（Candida albicans,Candida krusei,Candida glabrata,Candida parapsilosis,Oidium tropioale） were determined.The number of colony was calculated by plate counting method.Colony number-time curves of Itraconazole liposome against Candida krusei and Candida parapsilosis were measured and compared with that of Itraconazole injections.RESULTS：MIC,MBC and colony number-time curves of Itraconazole liposome against 5 kinds of deep fungus were similar to those of Itraconazole injection in experiments.CONCLUSION：The in vitro antifungal activity of Itraconazole liposome against 5 kinds of deep fungus is similar to that of Itraconazole injection.

关 键 词：伊曲康唑 脂质体 最小抑菌浓度 最小杀菌浓度 菌落数-时间曲线 

分 类 号：R978.5[医药卫生—药品] R944.9[医药卫生—药学]